Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model.
Cellular and molecular gastroenterology and hepatology
January 1, 2022
Ludovica Ceci et al. (20 authors)
Journal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Animal Study
Extracted Claims (6)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Short-term (1 wk) melatonin treatment | decrease | a ductular reaction and liver fibrosis | bile duct-ligated rats | - | reduces | #1 |
Short-term (1 wk) melatonin treatment | decrease | MT1 and clock genes | bile duct-ligated rats | - | down-regulation | #2 |
Chronic administration of melatonin | increase | liver histology | Mdr2-/- mice | - | improves | #3 |
Chronic administration of melatonin | increase | the circadian rhythm | Mdr2-/- mice | - | restores | #4 |
Melatonin | decrease | angiogenesis | - | - | decreased | #5 |
Melatonin | increase | maspin/GST activity | - | - | increased | #6 |
Abstract
BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is characterized by biliary senescence and hepatic fibrosis. Melatonin exerts its effects by interacting with Melatonin receptor 1 and 2 (MT1/MT2) melatonin receptors. Short-term (1 wk) melatonin treatment reduces a ductular reaction and liver fibrosis in bile duct-ligated rats by down-regulation of MT1 and clock genes, and in multidrug resistance gene 2 knockout (Mdr2 METHODS: Male wild-type and Mdr2 RESULTS: Chronic administration of melatonin to Mdr2 CONCLUSIONS: Melatonin improves liver histology and restores the circadian rhythm by interaction with MT1 through decreased angiogenesis and increased maspin/GST activity.
Medical Subject Headings (MeSH)
AnimalsCholangitis, SclerosingCholestasisDisease Models, AnimalDrinking WaterGlutathioneHumansLiver CirrhosisMaleMelatoninMicePhenotypeRatsReceptors, MelatoninTransferases
Study Links
PubMed ID35863741
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