Fish oil blunts lung function decrements induced by acute exposure to ozone in young healthy adults: A randomized trial.
Study Goal
The researchers aimed to determine whether fish oil (FO) supplementation could protect against lung function decrements caused by acute ozone (O₃) exposure.
Results Summary
The study found that FO supplementation reduced ozone-induced lung function decrements and airway inflammation compared to olive oil (OO) or no supplementation (CTL). FO also attenuated ozone-induced increases in certain inflammatory markers.
Population
43 participants (26 ± 4 years old; 47% female)
Effective Dosage
3 g/day
Duration
4 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
fish oil (FO) supplementation | decrease | FEV1 decrements | healthy adults | - | attenuated | #1 |
fish oil (FO) supplementation | decrease | FVC decrements | healthy adults | - | attenuated | #2 |
fish oil (FO) supplementation | decrease | FEV1/FVC decrements | healthy adults | - | attenuated | #3 |
fish oil (FO) supplementation | decrease | FEF25-75 decrements | healthy adults | - | attenuated | #4 |
fish oil (FO) supplementation | decrease | airway resistance | healthy adults | - | attenuated | #5 |
fish oil (FO) supplementation | decrease | airway inflammation | healthy adults | - | attenuated | #6 |
fish oil (FO) supplementation | decrease | systemic inflammation | healthy adults | - | attenuated | #7 |
fish oil (FO) supplementation | decrease | oxidative stress | healthy adults | - | attenuated | #8 |
fish oil (FO) supplementation | decrease | epithelial injury | healthy adults | - | attenuated | #9 |
fish oil (FO) supplementation | decrease | vascular injury | healthy adults | - | attenuated | #10 |
fish oil (FO) supplementation | decrease | lung function decrements | healthy adults | - | attenuated | #11 |
olive oil (OO) supplementation | no change | FEV1 decrements | healthy adults | - | did not attenuate | #12 |
olive oil (OO) supplementation | no change | FVC decrements | healthy adults | - | did not attenuate | #13 |
olive oil (OO) supplementation | no change | FEV1/FVC decrements | healthy adults | - | did not attenuate | #14 |
olive oil (OO) supplementation | no change | FEF25-75 decrements | healthy adults | - | did not attenuate | #15 |
olive oil (OO) supplementation | no change | airway resistance | healthy adults | - | did not attenuate | #16 |
olive oil (OO) supplementation | no change | airway inflammation | healthy adults | - | did not attenuate | #17 |
olive oil (OO) supplementation | no change | systemic inflammation | healthy adults | - | did not attenuate | #18 |
olive oil (OO) supplementation | no change | oxidative stress | healthy adults | - | did not attenuate | #19 |
olive oil (OO) supplementation | no change | epithelial injury | healthy adults | - | did not attenuate | #20 |
olive oil (OO) supplementation | no change | vascular injury | healthy adults | - | did not attenuate | #21 |
olive oil (OO) supplementation | no change | lung function decrements | healthy adults | - | did not attenuate | #22 |
ozone (O₃) exposure | decrease | FEV1 decrements | healthy adults | - | caused | #23 |
ozone (O₃) exposure | decrease | FVC decrements | healthy adults | - | caused | #24 |
ozone (O₃) exposure | decrease | FEV1/FVC decrements | healthy adults | - | caused | #25 |
ozone (O₃) exposure | decrease | FEF25-75 decrements | healthy adults | - | caused | #26 |
ozone (O₃) exposure | increase | airway resistance | healthy adults | - | caused | #27 |
ozone (O₃) exposure | increase | airway inflammation | healthy adults | - | caused | #28 |
ozone (O₃) exposure | increase | systemic inflammation | healthy adults | - | caused | #29 |
ozone (O₃) exposure | increase | oxidative stress | healthy adults | - | caused | #30 |
ozone (O₃) exposure | increase | epithelial injury | healthy adults | - | caused | #31 |
ozone (O₃) exposure | increase | vascular injury | healthy adults | - | caused | #32 |
ozone (O₃) exposure | decrease | lung function decrements | healthy adults | - | caused | #33 |
BACKGROUND: Over one-third of the U.S. population is exposed to unsafe levels of ozone (O METHODS: Forty-three participants (26 ± 4 years old; 47% female) were randomized to receive 3 g/day of FO, 3 g/day OO, or no supplementation (CTL) for 4 weeks prior to undergoing 2-hour exposures to filtered air and 300 ppb O RESULTS: Compared with filtered air, O CONCLUSION: FO supplementation appears to offer protective effects against lung function decrements caused by acute O