The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials.
Study Goal
The researchers aimed to investigate the efficacy of vitamin D in reducing depressive symptoms among adults in randomized placebo-controlled trials, excluding light therapy as an intervention.
Results Summary
The abstract does not report results specific to light therapy, as it was an exclusionary criterion in the study. The focus was on vitamin D's effects on depressive symptoms.
Population
Adults in general and clinical populations, including those with systemic diseases, but excluding individuals with bipolar disorder.
Effective Dosage
Not specified for light therapy.
Duration
Not specified for light therapy.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D | neutral | depression-linked physiology | - | - | may regulate | #1 |
vitamin D | neutral | depression | - | - | effect on | #2 |
vitamin D | decrease | depressive symptoms | adults | - | efficacy in reducing | #3 |
Neurosteroid and immunological actions of vitamin D may regulate depression-linked physiology. Meta-analyses investigating the effect of vitamin D on depression have been inconsistent. This meta-analysis investigated the efficacy of vitamin D in reducing depressive symptoms among adults in randomized placebo-controlled trials (RCT). General and clinical populations, and studies of ill individuals with systemic diseases were included. Light therapy, co-supplementation (except calcium) and bipolar disorder were exclusionary. Databases Medline, PsycINFO, CINAHL and The Cochrane Library were searched to identify relevant articles in English published before April 2022. Cochrane risk-of-bias tool (RoB 2) and GRADE were used to appraise studies. Forty-one RCTs (