Vitamin D Supplementation Modulates Platelet-Mediated Inflammation in Subjects With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial.
Study Goal
The researchers aimed to investigate the effect of vitamin D supplementation on platelet-mediated inflammation in vitamin-D-deficient type 2 diabetes (T2DM) patients.
Results Summary
Six months of vitamin D supplementation increased serum vitamin D3 and total 25(OH)D levels and reduced oxidative stress and platelet-mediated inflammation in T2DM patients, suggesting potential benefits for reducing cardiovascular risk.
Population
Vitamin-D-deficient type 2 diabetes (T2DM) patients.
Effective Dosage
Not specified in the abstract.
Duration
6 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation | increase | serum vitamin D3 levels | vitamin-D-deficient T2DM subjects | - | increases | #1 |
vitamin D supplementation | increase | total 25(OH)D levels | vitamin-D-deficient T2DM subjects | - | increases | #2 |
vitamin D supplementation | decrease | platelet-mediated inflammation | vitamin-D-deficient T2DM subjects | - | significantly reduced | #3 |
vitamin D supplementation | decrease | oxidative stress | vitamin-D-deficient T2DM subjects | - | significantly reduced | #4 |
vitamin D supportive therapy | decrease | disease progression | T2DM patients | - | may help to reduce or prevent | #5 |
vitamin D supportive therapy | decrease | cardiovascular risk | T2DM patients | - | may help to reduce or prevent | #6 |
BACKGROUND: Recently, our group identified increased platelet-mediated inflammation in type 2 diabetes (T2DM) patients, and it is a well-established risk factor for diabetes complications, particularly for the development of cardiovascular diseases (CVD). Furthermore, vitamin D is reported to play an important role in the modulation of platelet hyperactivity and immune function, although the effect of vitamin D on platelet-mediated inflammation is not well studied. Hence, we aimed to investigate the effect of vitamin D supplementation on platelet-mediated inflammation in T2DM patients. METHODS: After screening a total of 201 subjects, our randomized, double-blind, placebo-controlled trial included 59 vitamin-D-deficient T2DM subjects, and the participants were randomly assigned to placebo ( RESULTS: Six months of vitamin D supplementation increases the serum vitamin D3 and total 25(OH)D levels from the baseline ( CONCLUSION: Our study results provide evidence that vitamin D supportive therapy may help to reduce or prevent the disease progression and cardiovascular risk in T2DM patients by suppressing oxidative stress and platelet-mediated inflammation. CLINICAL TRIAL REGISTRATION: Clinical Trial Registry of India: CTRI/2019/01/016921.