Pre-germinated brown rice alleviates non-alcoholic fatty liver disease induced by high fructose and high fat intake in rat.
Study Goal
The researchers aimed to investigate the protective effects of pre-germinated brown rice (PGBR) on high fructose and high fat-induced non-alcoholic fatty liver disease (NAFLD) and cardiac complications in rodents.
Results Summary
PGBR significantly reduced body, hepatic, and cardiac weight gains, improved lipid homeostasis, and inhibited inflammation in rodents fed a high-fructose and high-fat diet. It also lowered elevated blood pressure, heart rate, liver function indices, and inflammatory markers.
Population
WKY rats (rodents)
Effective Dosage
Not specified
Duration
4 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
10% high-fructose-water (HFW) and high-fat-diet (HFD) | increase | body, hepatic and cardiac weight gains | WKY rats | - | significant increases | #1 |
10% high-fructose-water (HFW) and high-fat-diet (HFD) | increase | blood pressure and heart rate | WKY rats | - | enhanced | #2 |
10% high-fructose-water (HFW) and high-fat-diet (HFD) | increase | hypertriglyceridemia | WKY rats | - | observed | #3 |
10% high-fructose-water (HFW) and high-fat-diet (HFD) | increase | hyperuricemia | WKY rats | - | observed | #4 |
10% high-fructose-water (HFW) and high-fat-diet (HFD) | increase | liver function index (GPT levels) | WKY rats | - | higher | #5 |
10% high-fructose-water (HFW) and high-fat-diet (HFD) | increase | IL-6 and TNF-α levels of serum | WKY rats | - | elevated | #6 |
10% high-fructose-water (HFW) and high-fat-diet (HFD) | increase | TG level of liver | WKY rats | - | elevated | #7 |
10% high-fructose-water (HFW) and high-fat-diet (HFD) | increase | related protein expressions of lipid synthesis, inflammation, cardiac fibrosis, and hypertrophy | WKY rats | - | deteriorated | #8 |
pre-germinated brown rice (PGBR) | decrease | all above influenced parameters, additionally GOT | WKY rats | - | decreased | #9 |
pre-germinated brown rice (PGBR) | decrease | related protein expressions | WKY rats | - | decreased | #10 |
pre-germinated brown rice (PGBR) | decrease | HFW/HFD-induced NAFLD and cardiac complications | WKY rats | - | treated | #11 |
pre-germinated brown rice (PGBR) | increase | lipid homeostasis | WKY rats | - | improving | #12 |
pre-germinated brown rice (PGBR) | decrease | inflammation | WKY rats | - | inhibiting | #13 |
In past researches, we had been proved the action mechanism of pre-germinated brown rice (PGBR) to treat metabolic syndrome and diabetes mellitus. This study was to investigate the protective effect of PGBR in high fructose and high fat-induced non-alcoholic fatty liver disease (NAFLD) in rodents. WKY rats were divided into: Control group was fed normal drinking water and diet; FLD group was fed 10% high-fructose-water (HFW) and high-fat-diet (HFD); PGBR group was given HFW, and HFD mixed PGBR. After four weeks, the body, hepatic and cardiac weight gains of FLD group had significant increases than that of Control group. The enhanced blood pressure and heart rate, hypertriglyceridemia, hyperuricemia, and higher liver function index (GPT levels) were observed; meanwhile, the IL-6 and TNF-α levels of serum, and TG level of liver were also elevated in FLD group. The related protein expressions of lipid synthesis, inflammation, cardiac fibrosis, and hypertrophy were deteriorated by HFW/HFD. However, in treatment group, PGBR decreased all above influenced parameters, additionally GOT; and related protein expressions. PGBR treated HFW/HFD-induced NAFLD and cardiac complications might be via improving lipid homeostasis, and inhibiting inflammation. Together, PGBR could be used as a healthy food for controlling NAFLD and its' cardiac dysfunction.