Influence of Gluten-Free Diet on Gut Microbiota Composition in Patients with Coeliac Disease: A Systematic Review.
Study Goal
The researchers aimed to assess changes in microbiota composition during a gluten-free diet (GFD) in coeliac disease (CD) patients compared to healthy individuals and untreated CD patients.
Results Summary
The study found that a GFD did not fully restore commensal microorganism abundance but was associated with greater abundance of beneficial bacteria and lower presence of pathogenic bacteria linked to worsening CD symptoms. Bifidobacterium was less abundant in CD patients on GFD, while Bacteroides was more numerous, and Staphylococcaceae prevailed in untreated CD patients.
Population
212 patients with CD on GFD, compared to 174 healthy individuals and 176 untreated CD patients.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
gluten-free diet (GFD) | no change | commensal microorganism abundance | coeliac disease (CD) patients | null | was not able to fully restore | #1 |
gluten-free diet (GFD) | increase | selected beneficial bacteria | coeliac disease (CD) patients | null | was associated with the greater abundance of | #2 |
gluten-free diet (GFD) | decrease | pathogenic bacteria associated with worsening of CD symptoms | coeliac disease (CD) patients | null | was associated with the lower presence of | #3 |
null | decrease | Bifidobacterium | coeliac disease (CD) patients on GFD | null | was noticed to be less abundant | #4 |
null | increase | abundance of Bacteroides | coeliac disease (CD) patients on GFD | null | was more numerous | #5 |
null | increase | Staphylococcaceae | untreated CD patients | null | prevailed | #6 |
The aim of this study was to assess the changes in microbiota composition during a gluten-free diet (GFD) in coeliac disease (CD) patients. The systematic search followed databases such as PUBMED (MEDLINE), SCOPUS, WEB OF SCIENCE and EMBASE. Out of 843 initially screened papers, a total number of 13 research papers were included. A total of 212 patients with CD on GFD, in comparison to 174 healthy individuals and 176 untreated patients with CD, were examined. Analysis of the microbial community based primarily on faecal samples and duodenal biopsies. Bifidobacterium was noticed to be less abundant in the study group than in both control groups, while the abundance of Bacteroides was more numerous in the group of CD patients on GFD. Staphylococcaceae prevailed in untreated CD patients. Despite the fact that the GFD was not able to fully restore commensal microorganism abundance, the treatment was associated with the greater abundance of selected beneficial bacteria and lower presence of pathogenic bacteria associated with worsening of CD symptoms.