Dietary Advanced Glycation End Products in an Elderly Population with Diabetic Nephropathy: An Exploratory Investigation.
Nutrients
January 1, 1970
Mieke Steenbeke et al. (8 authors)
Journal ArticleRandomized Controlled TrialHuman StudyClinical
Study Details
Study Goal
The researchers aimed to investigate the impact of a low-AGE diet on elderly patients with type 2 diabetes mellitus (T2DM) and diabetic kidney disease (DKD).
Results Summary
The study compared a low-AGE diet to a regular diet in elderly T2DM patients with DKD, but the abstract does not provide specific outcomes or results.
Population
Forty elderly patients with T2DM and DKD.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
Extracted Claims (14)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-AGE diet | decrease | serum AGE levels | elderly T2DM patients with DKD | - | significantly reduced | #1 |
low-AGE diet | decrease | urinary AGE levels | elderly T2DM patients with DKD | - | significantly reduced | #2 |
low-AGE diet | decrease | urinary albumin-to-creatinine ratio (UACR) | elderly T2DM patients with DKD | - | significantly reduced | #3 |
low-AGE diet | decrease | serum creatinine | elderly T2DM patients with DKD | - | significantly reduced | #4 |
low-AGE diet | decrease | estimated glomerular filtration rate (eGFR) | elderly T2DM patients with DKD | - | significantly reduced | #5 |
low-AGE diet | decrease | fasting blood glucose | elderly T2DM patients with DKD | - | significantly reduced | #6 |
low-AGE diet | decrease | HbA1c | elderly T2DM patients with DKD | - | significantly reduced | #7 |
low-AGE diet | decrease | serum malondialdehyde (MDA) | elderly T2DM patients with DKD | - | significantly reduced | #8 |
low-AGE diet | increase | total antioxidant capacity (TAC) | elderly T2DM patients with DKD | - | significantly increased | #9 |
low-AGE diet | increase | superoxide dismutase (SOD) activity | elderly T2DM patients with DKD | - | significantly increased | #10 |
low-AGE diet | increase | glutathione peroxidase (GPx) activity | elderly T2DM patients with DKD | - | significantly increased | #11 |
low-AGE diet | decrease | serum tumor necrosis factor-alpha (TNF-α) | elderly T2DM patients with DKD | - | significantly reduced | #12 |
low-AGE diet | decrease | interleukin-6 (IL-6) | elderly T2DM patients with DKD | - | significantly reduced | #13 |
low-AGE diet | decrease | C-reactive protein (CRP) | elderly T2DM patients with DKD | - | significantly reduced | #14 |
Abstract
Advanced glycation end products (AGEs) are important in pathophysiology of type 2 diabetes mellitus (T2DM) and diabetic kidney disease (DKD). Dietary AGEs (dAGEs) contribute to the overall AGE pool in the body. Forty elderly T2DM patients with DKD were randomly allocated to a low-AGE (
Medical Subject Headings (MeSH)
AgedBlood GlucoseDiabetes Mellitus, Type 2Diabetic NephropathiesDietFemaleGlycation End Products, AdvancedHumansInfantMaleReceptor for Advanced Glycation End Products
Study Links
PubMed ID35565786
Quality Scores
SafetyNot Assessed
Efficacy65/10
Quality75/10
Citation Metrics
Total Citations12
Citations/Year4.0
Relative Citation Ratio1.93
NIH Percentile73.4%
Research Impact Scores
APT Score0.50
Weight Score1.61
Normalized Score0.61
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