Mediterranean Style Dietary Pattern with High Intensity Interval Training in Men with Prostate Cancer Treated with Androgen Deprivation Therapy: A Pilot Randomised Control Trial.
Study Goal
The researchers aimed to determine whether combining the Mediterranean diet with HIIT could improve cardiorespiratory fitness, body composition, and quality of life in men undergoing androgen deprivation therapy for prostate cancer.
Results Summary
The study found that the Mediterranean diet combined with HIIT significantly improved cardiorespiratory fitness (+4.9 mL·kg−1·min) and reduced body mass (−3.3 kg) compared to usual care. Clinically meaningful improvements were also observed in quality of life and cancer-related fatigue.
Population
Men with prostate cancer receiving androgen deprivation therapy (mean age 65.9 ± 7.8 years, BMI 29.6 ± 2.7 kg/m², ADT duration 33.8 ± 35.6 months).
Effective Dosage
HIIT protocol: 4 × 4 min at 85−95% heart rate peak, 3 times per week (starting at 12 weeks).
Duration
20 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Androgen deprivation therapy (ADT) | decrease | body composition | men with prostate cancer | - | deteriorate | #1 |
Androgen deprivation therapy (ADT) | decrease | lean mass | men with prostate cancer | - | reduced | #2 |
Androgen deprivation therapy (ADT) | increase | body and fat mass | men with prostate cancer | - | increased | #3 |
Androgen deprivation therapy (ADT) | increase | risk of cardiovascular morbidity | men with prostate cancer | - | increase | #4 |
The Mediterranean style dietary pattern (MED-diet) and high intensity interval training (HIIT) | decrease | these side effects | men treated with ADT | - | may synergistically alleviate | #5 |
The Mediterranean style dietary pattern (MED-diet) and high intensity interval training (HIIT) | increase | quality of life | men treated with ADT | - | improve | #6 |
MED-diet with HIIT | increase | cardiorespiratory fitness | men receiving ADT | +4.9 mL·kg−1·min | significantly improved | #7 |
MED-diet with HIIT | decrease | body mass | men receiving ADT | -3.3 kg | reduced | #8 |
MED-diet with HIIT | increase | quality of life | men receiving ADT | ≥3 points | Clinically meaningful (≥3 points) improvements | #9 |
MED-diet with HIIT | decrease | cancer-related fatigue | men receiving ADT | ≥3 points | Clinically meaningful (≥3 points) improvements | #10 |
MED-diet with HIIT | increase | cardiorespiratory fitness | men with prostate cancer treated with ADT | - | increased | #11 |
MED-diet with HIIT | decrease | body weight | men with prostate cancer treated with ADT | - | reduced | #12 |
Background: Androgen deprivation therapy (ADT) in prostate cancer has been shown to deteriorate body composition (reduced lean mass and increased body and fat mass) and increase the risk of cardiovascular morbidity. The Mediterranean style dietary pattern (MED-diet) and high intensity interval training (HIIT) may synergistically alleviate these side effects and improve quality of life in men treated with ADT. Methods: Twenty-three men (65.9 ± 7.8 years; body mass index: 29.6 ± 2.7 kg/m2; ADT duration: 33.8 ± 35.6 months) receiving ADT for ≥3 months were randomly assigned (1:1) to 20 weeks of usual care or the MED-diet (10 nutrition consults) with HIIT (4 × 4 min 85−95% heart rate peak, 3× week, starting at 12 weeks). Results: The MED-diet with HIIT significantly improved cardiorespiratory fitness (+4.9 mL·kg−1·min, p < 0.001), and body mass (−3.3 kg, p < 0.001) compared to the usual care group at 20 weeks. Clinically meaningful (≥3 points) improvements were seen in quality of life and cancer-related fatigue after 20 weeks. Conclusions: The MED-diet with HIIT increased cardiorespiratory fitness and reduced body weight in men with prostate cancer treated with ADT. Larger trials determining whether the MED-diet with HIIT translates to cardiovascular benefits are warranted.