Associations among serum insulin, calprotectin, and C-reactive protein concentrations in Miniature Schnauzers with idiopathic hyperlipidemia before and after feeding an ultra-low-fat diet.
Study Goal
The researchers aimed to determine how a low-fat diet affects indicators of insulin resistance and inflammatory biomarkers in Miniature Schnauzers with idiopathic hypertriglyceridemia.
Results Summary
The study found that a low-fat diet reduced serum insulin concentrations in dogs with hypertriglyceridemia, particularly in those achieving complete resolution of the condition. However, the increase in serum calprotectin concentrations after resolution of hypertriglyceridemia requires further investigation.
Population
Miniature Schnauzers with and without idiopathic hypertriglyceridemia.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
- | increase | serum glucose concentrations | Miniature Schnauzers with idiopathic hypertriglyceridemia | - | higher | #1 |
- | increase | serum calprotectin concentrations | Miniature Schnauzers with idiopathic hypertriglyceridemia | - | higher | #2 |
- | decrease | serum glucose and calprotectin concentrations | Miniature Schnauzers with idiopathic hypertriglyceridemia | ρ = -.28 | inversely correlated | #3 |
low-fat diet | decrease | median serum insulin concentrations | Miniature Schnauzers with idiopathic hypertriglyceridemia | 8.1 mU/L compared to 20.8 mU/L before dietary intervention | were | #4 |
low-fat diet | decrease | serum insulin concentrations | Dogs with complete resolution of HTGL after dietary intervention | - | had significantly lower | #5 |
low-fat diet | decrease | serum insulin concentrations | Miniature Schnauzers with idiopathic hypertriglyceridemia | - | Resolution of HTGL by dietary intervention is associated with a decrease in | #6 |
low-fat diet | increase | serum calprotectin concentrations | Miniature Schnauzers with idiopathic hypertriglyceridemia after resolution of HTGL | - | The implication of the increase in | #7 |
BACKGROUND: Miniature Schnauzers (MS) commonly have idiopathic hypertriglyceridemia (HTGL), which is associated with insulin resistance (IR) and a subclinical inflammatory phenotype. OBJECTIVES: Determine the association between indicators of IR and inflammatory biomarkers in MS with and without HTGL and identify how indicators of IR are affected by dietary intervention in MS with HTGL. ANIMALS: Seventy MS with HTGL and 79 MS without HTGL. In addition, 15 MS with HTGL were placed on a low-fat diet. METHODS: Serum concentrations of triglycerides, cholesterol, calprotectin, insulin, and glucose were compared between groups. RESULTS: Serum glucose and calprotectin concentrations (shown to be higher in MS with HTGL than in MS without HTGL) were inversely correlated (ρ = -.28; P < .001). After dietary intervention, median serum insulin concentrations were 8.1 mU/L compared to 20.8 mU/L before dietary intervention (P = .06). Dogs with complete resolution of HTGL after dietary intervention (5 dogs) had significantly lower serum insulin concentrations compared to baseline (P = .03). CONCLUSION AND CLINICAL IMPORTANCE: The subclinical inflammatory phenotype in MS with HTGL appears to be associated with IR. Resolution of HTGL by dietary intervention is associated with a decrease in serum insulin concentrations. The implication of the increase in serum calprotectin concentrations after resolution of HTGL warrants further study.