Circadian Rhythm and Melatonin in Liver Carcinogenesis: Updates on Current Findings.
Study Goal
The researchers aimed to explore the molecular mechanisms linking circadian rhythm disruption, melatonin, and liver cancer, and to assess their potential clinical applications for treatment and diagnosis.
Results Summary
The study summarized recent findings on the role of circadian rhythm and melatonin in chronic liver diseases and liver cancer, highlighting their potential therapeutic applications. It discussed the crosstalk between core clock genes and melatonin but did not provide specific efficacy data.
Population
Liver cancer patients and those with chronic liver diseases (e.g., alcoholic liver disease, non-alcoholic fatty liver disease).
Effective Dosage
Not available
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
circadian rhythm | increase | liver cancers | - | - | disruption has found in | #1 |
circadian rhythm | neutral | chronic liver diseases | - | - | played a role in | #2 |
circadian rhythm | neutral | liver cancer | - | - | played a role in | #3 |
melatonin | neutral | chronic liver diseases | - | - | played a role in | #4 |
melatonin | neutral | liver cancer | - | - | played a role in | #5 |
circadian rhythm | decrease | liver cancer | - | - | potential clinical application for the treatment of | #6 |
melatonin | decrease | liver cancer | - | - | potential clinical application for the treatment of | #7 |
Liver cancer, including hepatocellular carcinoma and cholangiocarcinoma, can be devastating if not treated early. The risk factors of liver cancer include alcoholic liver disease, non-alcoholic fatty liver disease, disruption of melatonin levels, and dysregulated circadian rhythm. The circadian rhythm is a 24-hour biological clock that regulates the physiological activities at both central and peripheral levels. Its molecular mechanism exists in every cell in mammals. Disruption of the circadian rhythm has found in liver cancers as an independent risk factor. This review summarized the most recent findings about the molecular mechanisms of circadian rhythm, the crosstalk between core clock genes and melatonin, as well as the role of circadian rhythm and melatonin played in chronic liver diseases and liver cancer. Finally, we discussed the potential clinical application of circadian rhythm and melatonin for the treatment of liver cancer and discussed future perspectives of how understanding the circadian rhythm in liver cancer progression could provide new clinical applications for liver cancer treatment and diagnosis.