Comparative efficacy of 11 non-pharmacological interventions on depression, anxiety, quality of life, and caregiver burden for informal caregivers of people with dementia: A systematic review and network meta-analysis.
Study Goal
The researchers aimed to compare and rank the efficacy of non-pharmacological interventions, including mindfulness-based intervention, on depression, anxiety, quality of life, and caregiver burden for informal caregivers of people with dementia.
Results Summary
The study found that mindfulness-based intervention might reduce depression in informal caregivers of people with dementia, but it did not show significant effects on anxiety, quality of life, or caregiver burden.
Population
Informal caregivers of community-dwelling people with dementia.
Effective Dosage
Not available
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Acceptance and commitment therapy | decrease | depression | informal caregivers of people with dementia | - | might reduce | #1 |
Behavioral activation | decrease | depression | informal caregivers of people with dementia | - | might reduce | #2 |
Mindfulness-based intervention | decrease | depression | informal caregivers of people with dementia | - | might reduce | #3 |
Multicomponent intervention | decrease | depression | informal caregivers of people with dementia | - | might reduce | #4 |
Psychoeducation | decrease | depression | informal caregivers of people with dementia | - | might reduce | #5 |
Cognitive behavioral therapy | decrease | depression | informal caregivers of people with dementia | - | might reduce | #6 |
Psychoeducation | decrease | anxiety | informal caregivers of people with dementia | - | was the only effective intervention against | #7 |
Support groups | increase | quality of life | informal caregivers of people with dementia | - | had a statistically significant effect on | #8 |
Case management | decrease | caregiver burden | informal caregivers of people with dementia | - | would be the effective interventions for | #9 |
Psychoeducation | decrease | caregiver burden | informal caregivers of people with dementia | - | would be the effective interventions for | #10 |
Multicomponent intervention | decrease | caregiver burden | informal caregivers of people with dementia | - | would be the effective interventions for | #11 |
BACKGROUND: In recent years, numerous dementia caregiving interventions for informal caregivers of community-dwelling people with dementia have been developed. However, it remains unclear which non-pharmacological interventions are effective and preferred for their depression and anxiety symptoms, quality of life, and caregiver burden. OBJECTIVES: To compare and rank the efficacy of different non-pharmacological interventions on depression, anxiety, quality of life, and caregiver burden for informal caregivers of people with dementia. DESIGN: A systematic review and network meta-analysis. METHODS: Relevant randomized controlled trials on the efficacy of non-pharmacological interventions for informal caregivers of people with dementia were extracted from seven electronic databases. A network meta-analysis was then performed to evaluate the relative efficacy of the non-pharmacological interventions for informal caregivers of people with dementia. The quality of the data was assessed using the Cochrane Risk of Bias tool. RESULTS: A total of 85 randomized controlled trials on 11 non-pharmacological interventions were included in the final analysis. Acceptance and commitment therapy, behavioral activation, mindfulness-based intervention, multicomponent intervention, psychoeducation, and cognitive behavioral therapy might reduce depression. Notably, psychoeducation was the only effective intervention against anxiety. Only support groups had a statistically significant effect on the quality of life. When considering decreasing caregiver burden, case management, psychoeducation, and multicomponent intervention would be the effective interventions. CONCLUSIONS: Several non-pharmacological interventions seemed to be effective in treating depression and anxiety, improving quality of life, and reducing caregiver burden for informal caregivers of people with dementia. Healthcare professionals should be encouraged to apply these non-pharmacological interventions for informal caregivers of people with dementia during routine care.