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Iron deficiency anemia in pregnancy.

Current opinion in obstetrics & gynecology
January 1, 1970
Irogue Igbinosa et al. (3 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to summarize the causes, consequences, treatment, and evaluation of iron deficiency anemia (IDA) in pregnancy, focusing on diagnostic and therapeutic approaches.

Results Summary

The study found that iron, in dietary, oral, and IV forms, effectively resolves anemia in pregnancy, with IV iron particularly beneficial in the third trimester. Modern IV iron formulations showed improved safety profiles and shorter infusion times.

Population

Pregnant individuals with iron deficiency anemia.

Effective Dosage

Oral iron with every other day dosing; IV iron dosage not specified.

Duration

Not specified.

Interactions

None mentioned.

Extracted Claims (7)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Oral iron
increase
absorption
-
-
absorption is improved
#1
Oral iron
decrease
anemia
patients able to tolerate
-
is effective
#2
modern generations of intravenous (IV) iron
decrease
infusion times
-
-
demonstrate shorter infusion times
#3
modern generations of intravenous (IV) iron
increase
safety profiles
-
-
demonstrate ... improved safety profiles
#4
universal IV iron supplementation
decrease
anemia
beyond 34 weeks of pregnancy
-
provide consideration for
#5
Iron, in dietary, oral, and IV forms
decrease
anemia
in pregnancy
-
has been found effective in resolving
#6
IV iron
decrease
anemia
Pregnant people with IDA in the third trimester
-
are more likely to benefit from
#7
Abstract

PURPOSE OF REVIEW: Anemia in pregnancy is associated with increased maternal and neonatal morbidity. There is increasing awareness amongst obstetricians about the need to screen for iron deficiency anemia (IDA), as well as growing literature on diagnosis and treatment. This review aims to summarize causes, consequences, treatment, and evaluation of IDA in pregnancy. RECENT FINDINGS: National guidelines provide varying guidance on diagnosis and treatment of IDA in pregnancy. Serum ferritin is a helpful adjunct for the diagnosis of IDA. Oral iron remains an option for treatment; absorption is improved with every other day dosing and is effective for patients able to tolerate. Emerging studies on modern generations of intravenous (IV) iron demonstrate shorter infusion times and improved safety profiles. Notably, recent UK guidelines provide consideration for universal IV iron supplementation for treatment of anemia beyond 34 weeks of pregnancy. SUMMARY: Iron, in dietary, oral, and IV forms, has been found effective in resolving anemia in pregnancy. Pregnant people with IDA in the third trimester are more likely to benefit from IV iron. Future studies designed and powered to assess maternal and perinatal morbidity indicators and blood transfusion rates can strengthen recommendations.

Medical Subject Headings (MeSH)
FemaleHumansInfant, NewbornIronIron DeficienciesPregnancyPregnancy Trimester, Third
Study Links
Quality Scores
Safety80
Efficacy85/10
Quality75/10
Citation Metrics
Total Citations8
Citations/Year2.7
Relative Citation Ratio1.57
NIH Percentile66.7%
Research Impact Scores
APT Score0.75
Weight Score1.57
Normalized Score0.81
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