Molecular Mechanisms Underlying the Bioactive Properties of a Ketogenic Diet.
Study Goal
The researchers aimed to explore the molecular mechanisms and therapeutic potential of a ketogenic diet in neurological disorders, metabolic syndrome, and cancer.
Results Summary
The study found that a ketogenic diet shifts cellular metabolism to pseudo-starvation and exerts physiological effects through metabolites acting as energy substrates, signaling molecules, and epigenetic modifiers, suggesting potential clinical applications in various diseases.
Population
Not specified (general discussion of potential therapeutic applications).
Effective Dosage
Not specified.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
ketogenic diet | neutral | health | - | - | has diverse effects | #1 |
ketogenic diet | neutral | neurological disorders, metabolic syndrome, and cancer | - | - | expected to have therapeutic value | #2 |
ketogenic diet | increase | cellular metabolism | - | pseudo-starvation | pronouncedly shifts | #3 |
ketogenic diet | neutral | various organs | - | - | exerts a variety of physiological functions | #4 |
The consumption of a high-fat, low-carbohydrate diet (ketogenic diet) has diverse effects on health and is expected to have therapeutic value in neurological disorders, metabolic syndrome, and cancer. Recent studies have shown that a ketogenic diet not only pronouncedly shifts the cellular metabolism to pseudo-starvation, but also exerts a variety of physiological functions on various organs through metabolites that act as energy substrates, signaling molecules, and epigenetic modifiers. In this review, we highlight the latest findings on the molecular mechanisms of a ketogenic diet and speculate on the significance of these functions in the context of the epigenome and microbiome. Unraveling the molecular basis of the bioactive effects of a ketogenic diet should provide solid evidence for its clinical application in a variety of diseases including cancer.