The effect of vitamin D supplementation on glycemic status of elderly people with prediabetes: a 12-month open-label, randomized-controlled study.
Study Goal
The researchers aimed to determine whether vitamin D supplementation improves glycemic markers in elderly individuals with prediabetes over 12 months.
Results Summary
Vitamin D supplementation significantly increased 25(OH)D concentrations and reduced fasting glucose at 6 months and glycated hemoglobin at 6 and 12 months compared to baseline.
Population
Greek individuals aged 60+ with prediabetes.
Effective Dosage
Weekly vitamin D (specific dosage not provided).
Duration
12 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation | increase | 25(OH)D concentrations | Greek people with prediabetes aged 60 years or above | - | demonstrated a significant increase | #1 |
vitamin D supplementation | decrease | fasting glucose | Greek people with prediabetes aged 60 years or above | 96.12 ± 5.51 vs 103.40 ± 12.05 mg/dl | was decreased | #2 |
vitamin D supplementation | decrease | glycated hemoglobin | Greek people with prediabetes aged 60 years or above | 5.82 ± 0.21% vs 5.87 ± 0.21% | was significantly lower | #3 |
vitamin D supplementation | decrease | glycated hemoglobin | Greek people with prediabetes aged 60 years or above | 5.80 ± 0.23% vs 5.87 ± 0.21% | was significantly lower | #4 |
BACKGROUND: Data on the efficacy of vitamin D in improving the glycemic status of elderly people with prediabetes are scarce. This open-label, randomized-controlled trial investigated the effect of vitamin D supplementation on glycemic markers of Greek people with prediabetes aged 60 years or above, over 12 months. RESEARCH DESIGN AND METHODS: Participants were randomized to a weekly vitamin D RESULTS: Supplemented participants demonstrated a significant increase in 25(OH)D concentrations at 3, 6, and 12 months compared to baseline . In the intervention group, fasting glucose was decreased at 6 months compared to baseline (96.12 ± 5.51 vs 103.40 ± 12.05 mg/dl, p < 0.01) and glycated hemoglobin was significantly lower at 6 and 12 months compared to baseline [5.82 ± 0.21% vs 5.87 ± 0.21%, p = 0.004 and 5.80 ± 0.23% vs 5.87 ± 0.21%, p < 0.001, respectively]. CONCLUSIONS: Vitamin D could be complementary to lifestyle change strategy for the management of prediabetes in the elderly. CLINICAL TRIAL REGISTRATION: ISRCTN51643592.