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Gluten-free diet - remedy for infertility or dangerous trend?

Ginekologia polska
May 5, 2022
Angelika Krawczyk et al. (7 authors)
Journal ArticleHuman Study
Study Details

Study Goal

The researchers aimed to examine the link between gluten elimination (via a gluten-free diet) and fertility, particularly in women with celiac disease or unexplained infertility.

Results Summary

The study found that a gluten-free diet improves fertility and pregnancy outcomes in women with celiac disease, including better results with assisted reproductive technology. However, gluten elimination in non-celiac women may risk malnutrition and adverse outcomes.

Population

Women with celiac disease, unexplained infertility, or non-celiac wheat sensitivity.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (7)
InterventionDirectionEndpointPopulationDosageImpactClaim #
-
increase
CD
women with unexplained infertility
three times
have three times higher risk
#1
gluten-free diet (GFD)
increase
fertility
women with unexplained infertility
-
is important to improve
#2
gluten-free diet (GFD)
increase
assisted reproductive technology (ART)
women diagnosed with CD and treated by GFD
-
have positive pregnancy outcomes including better effects
#3
Excluding gluten from diet
increase
risk of malnutrition
women without CD diagnosis
-
could bring adverse outcomes
#4
-
decrease
getting pregnant or with termination of pregnancy
-
-
is related to malnutrition which could be the cause of problems
#5
-
decrease
delayed menarche, early menopause and decrease of anti-Müllerian hormone (AMH)
women
-
is not only connected with unexplained infertility and adverse pregnancy outcomes, but also with
#6
non-celiac wheat sensitivity
increase
menstrual disorders
-
-
affects the reproductive system by increasing risk
#7
Abstract

Association between celiac disease (CD) and infertility has been a point of consideration for many years. There are lots of studies which present contradictory results. It is accepted that women with unexplained infertility have three times higher risk of CD compared to the healthy women. This finding leads to the conclusion that a gluten-free diet (GFD), as the only effective method of treatment CD, is important to improve fertility. It is observed that women diagnosed with CD and treated by GFD, have positive pregnancy outcomes including better effects of assisted reproductive technology (ART). Excluding gluten from diet by women without CD diagnosis could bring adverse outcomes, because the risk of malnutrition if diet is unbalanced. On the other hand, some research show that not only GFD but CD is related to malnutrition which could be the cause of problems with getting pregnant or with termination of pregnancy. Regarding CD influence on women's reproductive system, it is not only connected with unexplained infertility and adverse pregnancy outcomes, but also with delayed menarche, early menopause and decrease of anti-Müllerian hormone (AMH). What is more, non-celiac wheat sensitivity affects the reproductive system by increasing risk of menstrual disorders too. The main aim of this paper is presenting scientific facts about the link between gluten elimination and fertility. It is very important to provide patients with reliable fact-checked information in the context of their symptoms.

Medical Subject Headings (MeSH)
PregnancyHumansFemaleDiet, Gluten-FreeInfertilityCeliac DiseaseFertilityMalnutrition
Study Links
Quality Scores
Safety70
Efficacy80/10
Quality65/10
Citation Metrics
Total Citations1
Citations/Year0.3
Relative Citation Ratio0.17
NIH Percentile8.5%
Research Impact Scores
APT Score0.25
Weight Score2.01
Normalized Score0.73
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