D-Chiro-inositol and PCOS: between myth and reality. The never-ending story.
Study Goal
The researchers aimed to clarify the use of inositols (Myo-inositol and D-chiro-Inositol) for treating PCOS and explore D-Chiro-Inositol's properties as an ovarian aromatase inhibitor.
Results Summary
The study highlights the significant role of inositol therapy in PCOS, particularly Myo-inositol and D-chiro-Inositol, in restoring ovary function and mitigating PCOS consequences. It also discusses D-Chiro-Inositol's potential as an ovarian aromatase inhibitor.
Population
Women of reproductive age with polycystic ovary syndrome (PCOS).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Diet and lifestyle modifications | increase | ovary function | patients with polycystic ovary syndrome (PCOS) | - | can fully restore | #1 |
Diet and lifestyle modifications | decrease | PCOS consequences | a certain number of patients with polycystic ovary syndrome (PCOS) | - | can avoid | #2 |
inositol therapy | neutral | - | patients with polycystic ovary syndrome (PCOS) | - | has confirmed the significant role of | #3 |
Myo-inositol | neutral | - | patients with polycystic ovary syndrome (PCOS) | - | has confirmed the significant role of | #4 |
D-chiro-Inositol | neutral | - | patients with polycystic ovary syndrome (PCOS) | - | has confirmed the significant role of | #5 |
D-Chiro-Inositol | neutral | ovarian aromatase inhibitor | - | - | properties as | #6 |
Polycystic ovary syndrome (PCOS) is one of the most common disorders among women of reproductive age and can be diagnosed when at least two of the following criteria are present: chronic ovulatory disorder, clinical and/or biochemical hyperandrogenism, and polycystic ovaries. Diet and lifestyle modifications are the main therapeutic intervention and they can fully restore ovary function and avoid PCOS consequences in a certain number of patients. However, prescription of medications or dietary supplements is often needed. The literature has confirmed the significant role of inositol therapy in PCOS, with particular reference to Myo-inositol and D-chiro-Inositol. The aim of this review is to clarify the use of inositols for the treatment of PCOS and the recent scientific theories about D-Chiro-Inositol properties as an ovarian aromatase inhibitor.