Effect of Vitamin D Supplementation on Glycemic Control in Prediabetes: A Meta-Analysis.
Study Goal
The researchers aimed to evaluate the effectiveness of Vitamin D supplementation in improving prediabetes-related indicators.
Results Summary
The study found mixed and controversial results regarding Vitamin D's impact on prediabetes markers such as BMI, FBG, 2h-PG, HbA1c, HOMA-IR, HOMA-B, and FINS.
Population
Prediabetes patients (specific demographics not detailed in the abstract).
Effective Dosage
Not specified in the abstract.
Duration
Not specified in the abstract.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation | increase | prediabetes | - | - | improvement | #1 |
vitamin D supplementation | neutral | body mass index (BMI) | - | - | reported | #2 |
vitamin D supplementation | neutral | fasting blood glucose (FBG) | - | - | reported | #3 |
vitamin D supplementation | neutral | 2 h oral glucose tolerance test plasma glucose (2h-PG) | - | - | reported | #4 |
vitamin D supplementation | neutral | hemoglobin A1c (HbA1c) | - | - | reported | #5 |
vitamin D supplementation | neutral | insulin resistance by homeostasis model assessment (HOMA-IR) | - | - | reported | #6 |
vitamin D supplementation | neutral | homeostasis model assessment of β-cell function (HOMA-B) | - | - | reported | #7 |
vitamin D supplementation | neutral | fasting insulin (FINS) | - | - | reported | #8 |
Clinical research results of vitamin D supplementation in the improvement of prediabetes remain controversial. Accordingly, a literature search was conducted of PubMed, Embase (Ovid), and Web of Science prior to 9 November 2021. Randomized controlled studies reported that the following indicators were included: body mass index (BMI), fasting blood glucose (FBG), 2 h oral glucose tolerance test plasma glucose (2h-PG), hemoglobin A1c (HbA1c), insulin resistance by homeostasis model assessment (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-B), and fasting insulin (FINS). Twenty-nine articles (