A Low-Protein Diet with a Renal-Specific Oral Nutrition Supplement Helps Maintain Nutritional Status in Patients with Advanced Chronic Kidney Disease.
Study Goal
The researchers aimed to determine whether a low-protein diet supplemented with a renal-specific oral nutrition supplement (RONS) could improve nutritional status and delay renal function decline in patients with advanced chronic kidney disease (CKD).
Results Summary
The study found that RONS use increased energy intake, maintained serum albumin and nutritional status, improved quality of life, and slightly preserved residual renal function, though eGFR decreased modestly over time. Body weight and handgrip strength significantly improved after 6 months.
Population
Patients aged 18+ with stage 3b-5 CKD (eGFR 10-45 mL/min/1.73 m²), serum albumin ≥3.0 g/dL, and BMI ≤30 kg/m².
Effective Dosage
One serving of RONS daily.
Duration
6 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-protein diet (LPD) including a renal-specific oral nutrition supplement (RONS) | increase | energy intake | patients with stage 3b-5 CKD | - | increased | #1 |
low-protein diet (LPD) including a renal-specific oral nutrition supplement (RONS) | no change | serum albumin | patients with stage 3b-5 CKD | - | maintained | #2 |
low-protein diet (LPD) including a renal-specific oral nutrition supplement (RONS) | no change | nutritional status | patients with stage 3b-5 CKD | - | maintained | #3 |
low-protein diet (LPD) including a renal-specific oral nutrition supplement (RONS) | no change | quality of life | patients with stage 3b-5 CKD | - | maintained | #4 |
low-protein diet (LPD) including a renal-specific oral nutrition supplement (RONS) | increase | body weight | patients with stage 3b-5 CKD | - | increased significantly | #5 |
low-protein diet (LPD) including a renal-specific oral nutrition supplement (RONS) | increase | handgrip strength | patients with stage 3b-5 CKD | - | increased significantly | #6 |
low-protein diet (LPD) including a renal-specific oral nutrition supplement (RONS) | decrease | eGFR | patients with stage 3b-5 CKD | - | slightly decreased | #7 |
low-protein diet (LPD) including a renal-specific oral nutrition supplement (RONS) | no change | residual renal function | patients with stage 3b-5 CKD | - | preserved | #8 |
low-protein diet (LPD) including a renal-specific oral nutrition supplement (RONS) | decrease | renal function decline | patients with non-dialysis advanced CKD | - | delay | #9 |
A low-protein diet (LPD) is recommended to patients with non-dialysis advanced chronic kidney disease (CKD) for delaying renal function decline. However, this approach potentially prevents an adequate calorie and micronutrient intake. We examined the influence of an LPD including a renal-specific oral nutrition supplement (RONS) on the nutrition status of patients with stage 3b-5 CKD. This multicenter, open-label study prospectively enrolled patients over 18 years of age, with an estimated glomerular filtration rate (eGFR) between 10 and 45 mL/min/1.73 m2, serum albumin ≥3.0 g/dL, and body mass index ≤30 kg/m2. All participants implemented the LPD with one serving of RONS daily for 6 months. Daily energy intake, nutrition status, renal function, and quality of life were assessed before and after the intervention. Of 53 enrolled patients, 35 (66.0%) completed the study. We found that RONS use increased patients' energy intake and maintained their serum albumin, nutritional status, and quality of life. Body weight and handgrip strength increased significantly at 6 months after enrollment (p = 0.0357); eGFR slightly decreased at 3 and 6 months after enrollment, suggesting that patients' residual renal function was preserved. Our findings support the conclusion that patients with non-dialysis advanced CKD may benefit from additional RONS besides their regular diet. Patients with advanced CKD receiving RONS might achieve better nutrition and delay renal function decline.