Magnesium supplementation for glycemic status in women with gestational diabetes: a systematic review and meta-analysis.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
magnesium supplementation | decrease | fasting plasma glucose | women with gestational diabetes | SMD = -0.99; 95% CI = -1.28 to -0.70 | significantly reduced | #1 |
magnesium supplementation | decrease | serum insulin levels | women with gestational diabetes | SMD = -0.53; 95% CI = -0.92 to -0.14 | significantly reduced | #2 |
magnesium supplementation | decrease | homeostasis model assessment of insulin resistance | women with gestational diabetes | SMD = -0.51; 95% CI = -0.90 to -0.12 | significantly reduced | #3 |
magnesium supplementation | decrease | glycemic control | women with gestational diabetes | - | benefits | #4 |
OBJECTIVE: The effect of magnesium supplementation on glycemic status in women with gestational diabetes remains controversial and this meta-analysis aims to explore the efficacy of magnesium supplementation for gestational diabetes. METHODS: We have searched PubMed, Excerpta Medica database, Web of science, Elton B. Stephens. Company, and Cochrane library databases. The meta-analysis included randomized controlled trials (RCTs) assessing the effect of magnesium supplementation for gestational diabetes and was performed using the random-effect model. RESULTS: Four RCTs were included in the meta-analysis. Overall, compared with placebo in gestational diabetes, magnesium supplementation was associated with significantly reduced fasting plasma glucose (standard mean difference [SMD] = -0.99; 95% confidence interval [CI] = -1.28 to -0.70; CONCLUSION: Magnesium supplementation benefits glycemic control for gestational diabetes.