Efficacy of Creatine Supplementation Combined with Resistance Training on Muscle Strength and Muscle Mass in Older Females: A Systematic Review and Meta-Analysis.
Study Goal
The researchers aimed to determine whether creatine supplementation combined with resistance training enhances muscle strength and mass in older females compared to resistance training alone.
Results Summary
The study found that creatine supplementation combined with resistance training augmented gains in muscle strength and mass in older females compared to resistance training alone, though sex differences may influence effectiveness.
Population
Older females with sarcopenia or age-related muscle loss.
Effective Dosage
Not specified in the abstract.
Duration
Not specified in the abstract.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Resistance training (RT) | decrease | indices of sarcopenia | - | - | is well established to be an effective intervention to counter | #1 |
creatine supplementation (Cr) to RT | increase | muscle strength and muscle mass | - | - | augments gains in | #2 |
creatine supplementation (Cr) to RT | increase | upper- and lower-body strength and muscle mass | older females | - | augments gains in | #3 |
Sarcopenia refers to the age-related loss of muscle strength and muscle mass, which is associated with a reduced quality of life, particularly in older females. Resistance training (RT) is well established to be an effective intervention to counter indices of sarcopenia. Accumulating research indicates that the addition of creatine supplementation (Cr) to RT augments gains in muscle strength and muscle mass, compared to RT alone. However, some evidence indicates that sex differences may alter the effectiveness of Cr. Therefore, we systematically reviewed randomized controlled trials (RCTs) investigating the efficacy of Cr + RT on measures of upper- and lower-body strength and muscle mass in older females. A systematic literature search was performed in nine electronic databases. Ten RCTs (