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Exploring Effects of Aerobic Exercise and Mindfulness Training on Cognitive Function in Older Adults at Risk of Dementia: A Feasibility, Proof-of-Concept Study.

American journal of Alzheimer's disease and other dementias
January 1, 2021
Elena Salmoirago-Blotcher et al. (9 authors)
Journal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov'tHuman StudyClinical
Study Details

Study Goal

The researchers aimed to explore the feasibility, acceptability, and preliminary effects of mindfulness training (MT) on cognitive function in older individuals at risk of dementia.

Results Summary

At the end of treatment, mindfulness training (MT) showed higher cognitive function scores (ZAVEN) compared to usual care (UC) and aerobic training (AT), with a similar pattern observed at a 6-month follow-up. No significant differences were found for the combined MT + AT group.

Population

Older individuals (mean age 70.1 years) at risk of dementia.

Effective Dosage

Not available

Duration

Duration of intervention not specified (follow-up at 6 months).

Interactions

None mentioned

Extracted Claims (4)
InterventionDirectionEndpointPopulationDosageImpactClaim #
mindfulness training (MT)
increase
ZAVEN scores
older individuals at risk of dementia
b = .43, P =.03
had higher ZAVEN scores than UC
#1
mindfulness training (MT)
increase
ZAVEN scores
older individuals at risk of dementia
b = .26, P = .10
had higher ZAVEN scores than AT
#2
MT + AT
no change
ZAVEN scores
older individuals at risk of dementia
-
no differences were seen
#3
mindfulness training (MT)
increase
cognitive function
older individuals at risk of dementia
-
may improve cognitive function
#4
Abstract

OBJECTIVES: This study sought to explore feasibility, acceptability, and preliminary effects of aerobic training (AT), mindfulness training (MT), or both (MT + AT) on cognitive function in older individuals at risk of dementia. METHOD: Participants were randomized to AT, MT, both, or usual care (UC). Z-scores of attention, verbal fluency, and episodic memory for non-demented adults (ZAVEN) were computed at baseline, end of treatment (EOT), and 6 months since baseline. RESULTS: Of the 36 enrolled participants (12 M, 24 F, mean age = 70.1 years), 97% were retained in the study at 6 months. At EOT, MT had higher ZAVEN scores than UC (b = .43, P =.03) and AT (b = .26, P = .10), while no differences were seen with MT + AT. A similar pattern was observed at a 6 month follow-up (all DISCUSSION: MT may improve cognitive function in older individuals at risk of dementia. These preliminary findings need to be confirmed in a fully powered RCT.

Medical Subject Headings (MeSH)
AgedCognitionDementiaExerciseExercise TherapyFeasibility StudiesHumansMindfulness
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality80/10
Citation Metrics
Total Citations5
Citations/Year1.3
Relative Citation Ratio0.59
NIH Percentile32.1%
Research Impact Scores
APT Score0.25
Weight Score2.35
Normalized Score0.66
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Exploring Effects of Aerobic Exercise and Mindfulness Traini... | Panacea Index