The role of gluten-free diet in nonalcoholic fatty liver disease development.
Study Goal
The researchers aimed to evaluate the risk of non-alcoholic fatty liver disease (NAFLD) in celiac disease patients adhering to a gluten-free diet (GFD).
Results Summary
The systematic review found that GFD in celiac disease patients may increase the risk of NAFLD due to consumption of products rich in saturated fats and carbohydrates, leading to hepatic steatosis and inflammation. Eight studies supported this association over follow-up periods ranging from six months to a median of 10 years.
Population
Celiac disease patients adhering to a gluten-free diet.
Effective Dosage
Not Assessed
Duration
Six months to a median of 10 years.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
gluten-free diet | increase | non-alcoholic fatty liver disease | Celiac Disease patients | - | has been related to the onset | #1 |
gluten-free diet | increase | NAFLD | CD patients | - | may be a risk factor for the onset | #2 |
gluten-free diet | increase | hepatic steatosis and inflammation | - | - | plays a key role in NAFLD for consumption of products rich in saturated fats and carbohydrates that promotes accumulation of lipids and lead to | #3 |
OBJECTIVE: Celiac Disease (CD) is an autoimmune disease involving the small bowel, generated by the ingestion of gluten-containing foods in genetically predisposed subjects. Currently, the unique therapy for CD is the absolute adherence to gluten-free diet, but this treatment has been related to the onset of non-alcoholic fatty liver disease (NAFLD). In this systematic review, we provide an update from the most recent studies on the risk of developing NAFLD patients adhering to GFD. MATERIALS AND METHODS: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria, we performed a systematic literature search on PubMed and Google Scholar from 2012 to 2021. RESULTS: In the present systematic review, eight studies investigated how GFD in CD patients may be a risk factor for the onset of NAFLD from a minimum of six months to the maximum follow-up period represented by a median of 10 years. CONCLUSIONS: Present systematic review evaluates how GFD plays a key role in NAFLD for consumption of products rich in saturated fats and carbohydrates that promotes accumulation of lipids and lead to hepatic steatosis and inflammation.