Oral Iron Supplementation in Pregnancy: Current Recommendations and Evidence-Based Medicine.
Study Goal
To evaluate the evidence on universal iron supplementation in pregnancy for preventing maternal anemia.
Results Summary
Most studies indicated improved hematological parameters and reduced maternal anemia risk with iron supplementation, but did not correlate these improvements with clinical benefits in pregnant women without prior anemia. The recommendation strength was rated as SORT C, indicating controversy.
Population
Pregnant women
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
universal iron supplementation in pregnancy | increase | hematological parameters | pregnant women | - | improvement | #1 |
supplementary iron | decrease | maternal anemia risk | pregnant women | - | reduction | #2 |
supplementary iron | no change | clinical parameters | pregnant women without previous anemia | - | do not correlate this improvement | #3 |
OBJECTIVE: To review the evidence about universal iron supplementation in pregnancy to prevent maternal anemia. METHODS: Bibliographic research of randomized and controlled clinical trials, meta-analyses, systematic reviews, and clinical guidelines, published between August 2009 and August 2019, using the MeSH terms: RESULTS: We included six clinical guidelines, three meta-analyses and one randomized controlled clinical trial. DISCUSSION: Most articles point to the improvement of hematological parameters and reduction of maternal anemia risk, with supplementary iron. However, they do not correlate this improvement in pregnant women without previous anemia with the eventual improvement of clinical parameters. CONCLUSION: Universal iron supplementation in pregnancy is controversial, so we attribute a SORT C recommendation strength. Rever a evidência sobre a necessidade de suplementação universal de ferro na gravidez para prevenção de anemia materna. MéTODOS: Pesquisa bibliográfica de ensaios clínicos aleatorizados e controlados, metanálises, revisões sistemáticas e normas de orientação clínica, publicados entre agosto de 2009 e agosto de 2019, utilizando os termos MeSH: