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An Update on Assessment, Therapeutic Management, and Patents on Insomnia.

BioMed research international
January 1, 2021
Amit Porwal et al. (4 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to review various pharmacological treatments for insomnia, including melatonin receptor agonists, and assess their effectiveness and safety.

Results Summary

The abstract mentions melatonin receptor agonists as one of the pharmacological treatments for insomnia but does not provide specific efficacy data for melatonin itself. It notes that evidence favoring the effectiveness of various prescriptions for insomnia is limited, except in cases related to circadian disturbances.

Population

Individuals with insomnia, particularly those with circadian disturbances, restless leg syndrome, or mood disorders.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (12)
InterventionDirectionEndpointPopulationDosageImpactClaim #
cognitive behavioural therapy for insomnia
neutral
insomnia
-
-
incorporated as an alternative for treatment
#1
orexin antagonists
neutral
insomnia
-
-
incorporated as an alternative for treatment
#2
z-drugs
neutral
insomnia
-
-
incorporated as an alternative for treatment
#3
benzodiazepines
neutral
insomnia
-
-
incorporated as an alternative for treatment
#4
selective histamine H1 antagonists
neutral
insomnia
-
-
incorporated as an alternative for treatment
#5
nonselective antihistamines
neutral
insomnia
-
-
incorporated as an alternative for treatment
#6
melatonin receptor agonists
neutral
insomnia
-
-
incorporated as an alternative for treatment
#7
antipsychotics
neutral
insomnia
-
-
incorporated as an alternative for treatment
#8
antidepressants
neutral
insomnia
-
-
incorporated as an alternative for treatment
#9
anticonvulsants
neutral
insomnia
-
-
incorporated as an alternative for treatment
#10
different prescriptions for the treatment of insomnia
no change
insomnia
individuals whose insomnia is due to restless leg syndrome, depression/mood disorder, or/and circadian disturbance
insignificant
insignificant proof favouring the effectiveness
#11
other pharmacological agents producing sedation
neutral
insomnia therapy
-
-
should be prescribed with care
#12
Abstract

Insomnia is an ordinary situation related to noticeable disability in function and quality of life, mental and actual sickness, and mishappenings. It represents more than 5.5 million appointments to family doctors every year. Nonetheless, the ratio of insomniacs who are treated keeps on being low, demonstrating the requirement for proceeding with advancement and dispersal of effective treatments. Accordingly, it becomes significant to provide a compelling treatment for clinical practice. It indicates a need for the determination of various critical viewpoints for the evaluation of insomnia along with various accessible alternatives for treatment. These alternatives incorporate both nonpharmacological therapy, specifically cognitive behavioural therapy for insomnia, and a number of pharmacological treatments like orexin antagonists, "z-drugs," benzodiazepines, selective histamine H1 antagonists, nonselective antihistamines, melatonin receptor agonists, antipsychotics, antidepressants, and anticonvulsants. Besides in individuals whose insomnia is due to restless leg syndrome, depression/mood disorder, or/and circadian disturbance, there is insignificant proof favouring the effectiveness of different prescriptions for the treatment of insomnia though they are widely used. Other pharmacological agents producing sedation should be prescribed with care for insomnia therapy because of greater risk of next-day sleepiness along with known adverse effects and toxicities. This review is also aimed at providing an update on various patents on dosage forms containing drugs for insomnia therapy.

Medical Subject Headings (MeSH)
Antidepressive AgentsAntipsychotic AgentsCognitive Behavioral TherapyHistamine H1 AntagonistsHumansHypnotics and SedativesQuality of LifeSleep Initiation and Maintenance DisordersTreatment Outcome
Study Links
Quality Scores
SafetyNot Assessed
Efficacy60/10
Quality70/10
Citation Metrics
Total Citations10
Citations/Year2.5
Relative Citation Ratio1.20
NIH Percentile57.1%
Research Impact Scores
APT Score0.75
Weight Score2.28
Normalized Score0.58
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An Update on Assessment, Therapeutic Management, and Patents... | Panacea Index