The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies.
Study Goal
The researchers aimed to understand the association between Vitamin D and alterations in gastrointestinal microbiota, focusing on supplementation, dietary intake, and serum levels.
Results Summary
Vitamin D supplementation was associated with significant changes in microbiome composition, particularly in gut microbiota. The study included both interventional and observational designs, with 25 studies reviewed.
Population
Human subjects (specific population not detailed in the abstract).
Effective Dosage
Not specified in the abstract.
Duration
Not specified in the abstract.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D (VD) | neutral | immune system | - | - | has a number of extra-skeletal functions | #1 |
Vitamin D (VD) | neutral | gut microbiota | - | - | mediated by the modulation of | #2 |
VD supplementation | increase | microbiome composition | human subjects | - | was found to be associated with a significant change in | #3 |
Recent evidence has shown a number of extra-skeletal functions of Vitamin D (VD), primarily involving the immune system. One of these functions is mediated by the modulation of gut microbiota, whose alterations are linked to many diseases. Our purpose is to contribute to the understanding of existing evidence on the association between VD and gastrointestinal microbiota alterations. A systematic review of studies with human subjects has been conducted up to January 2021. We included publications reporting the association between gut microbiota and VD, including VD supplementation, dietary VD intake and/or level of 25(OH)D. We identified 25 studies: 14 were interventional and 11, observational. VD supplementation was found to be associated with a significant change in microbiome composition, in particular of