Vitamin E supplementation in inflammatory skin diseases.
Study Goal
The researchers aimed to evaluate the role of vitamin E supplementation in preventing and treating atopic dermatitis and psoriasis, as well as its effects on Alzheimer's disease progression and respiratory infections in older patients.
Results Summary
Vitamin E supplementation showed a positive role in slowing Alzheimer's disease progression, protecting against respiratory infections, and potentially benefiting atopic dermatitis and psoriasis, though further evidence is needed due to study limitations.
Population
Patients with vitamin E deficiency due to fat malabsorption, older patients, and individuals with atopic dermatitis or psoriasis.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin E supplementation | neutral | vitamin E deficiency due to fat malabsorption | patients | - | is recommended | #1 |
The addition of vitamin E to the diet | decrease | Alzheimer's disease progression | - | - | slows | #2 |
The addition of vitamin E to the diet | decrease | against respiratory infections | older patients | - | protects | #3 |
vitamin E supplementation | increase | atopic dermatitis and psoriasis | - | - | point to a positive role | #4 |
Vitamin E is a powerful lipophilic antioxidant that protects membranes from lipid peroxidation, and consequently, oxidative damage. Oxidative stress plays a role in the development of neurodegenerative diseases. Vitamin E supplementation is recommended in patients with vitamin E deficiency due to fat malabsorption. The addition of vitamin E to the diet slows Alzheimer's disease progression and protects older patients against respiratory infections. Recent studies also point to the involvement of oxidative stress in the pathology of immune-mediated skin diseases, such as atopic dermatitis and psoriasis. We reviewed the available clinical trials that investigated the role of vitamin E supplementation in preventing and treating atopic dermatitis and psoriasis. Data from these studies point to a positive role of vitamin E supplementation in these diseases. Still, due to limitations in study design, further evidence is needed to reach a definite conclusion.