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Properties of the Cognitive Function Battery for the MIND Diet Intervention to Prevent Alzheimer's Disease.

Journal of the International Neuropsychological Society : JINS
September 1, 2022
Kristin R Krueger et al. (7 authors)
Journal ArticleRandomized Controlled TrialResearch Support, N.I.H., ExtramuralHuman StudyClinical
Study Details

Study Goal

The researchers aimed to evaluate the validity of the cognitive battery used in the MIND Diet Intervention to measure cognitive decline and brain atrophy in older adults at risk for Alzheimer's dementia.

Results Summary

The study found that the MIND cognitive battery effectively measured four distinct cognitive domains (executive function, perceptual speed, episodic memory, and semantic memory) and showed expected associations with age, education, and cognitive activity. The results support the battery's validity for use in diet intervention trials.

Population

Older adults (average age 70 years) at risk for Alzheimer's dementia.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (2)
InterventionDirectionEndpointPopulationDosageImpactClaim #
MIND diet
decrease
cognitive decline
older adults at risk for Alzheimer's dementia
-
slowing
#1
MIND diet
decrease
brain atrophy
older adults at risk for Alzheimer's dementia
-
reducing
#2
Abstract

OBJECTIVE: To evaluate the properties of the cognitive battery used in the MIND Diet Intervention to Prevent Alzheimer's Disease. The MIND Diet Intervention is a randomized control trial to determine the relative effectiveness of the MIND diet in slowing cognitive decline and reducing brain atrophy in older adults at risk for Alzheimer's dementia. METHODS: The MIND cognitive function battery was administered at baseline to 604 participants of an average age of 70 years, who agreed to participate in the diet intervention study, and was designed to measure change over time. The battery included 12 cognitive tests, measuring the 4 cognitive domains of executive function, perceptual speed, episodic memory, and semantic memory. We conducted a principal component analysis to examine the consistency between our theoretical domains and the statistical performance of participants in each domain. To further establish the validity of each domain, we regressed the domain scores against a late-life cognitive activity score, controlling for age, race, sex, and years of education. RESULTS: Four factors emerged in the principal component analyses that were similar to the theoretical domains. In regression equations, we found the expected associations with age, education, and late-life cognitive activity with each of the four cognitive domains. CONCLUSIONS: These results indicate that the MIND cognitive battery is a comprehensive and valid battery of four separate domains of cognitive function that can be used in diet intervention trials for older adults.

Medical Subject Headings (MeSH)
AgedAlzheimer DiseaseCognitionCognitive DysfunctionExecutive FunctionHumansNeuropsychological Tests
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality85/10
Citation Metrics
Total Citations6
Citations/Year2.0
Relative Citation Ratio0.92
NIH Percentile47.1%
Research Impact Scores
APT Score0.50
Weight Score2.64
Normalized Score0.67
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