Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review.
Study Goal
The researchers aimed to evaluate the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals against doxorubicin-induced cardiotoxicity.
Results Summary
The review found that antioxidants from edible plants could potentially reduce oxidative stress and cardiotoxicity caused by doxorubicin, based on various in vivo and in vitro models. The studies highlighted the beneficial role of these antioxidants in mitigating cardiac damage during chemotherapy.
Population
Models in vivo and in vitro (not specified for humans).
Effective Dosage
Not available
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants | decrease | the toxicity of antitumor drugs | - | - | could decrease | #1 |
an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants | decrease | the risk of cardiac failure | - | - | could diminish | #2 |
Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic-doxorubicin-as the oxidative stress- and cardiotoxicity-inducing agent.