Effectiveness and Safety of a Very Low-Calorie Ketogenic Diet on Weight Regain Following Bariatric Surgery.
Study Goal
The researchers aimed to assess the effectiveness and safety of a very low-calorie ketogenic diet (VLCKD) in patients who experienced insufficient weight loss or weight regain after Roux-en-Y gastric bypass (RYGB) surgery.
Results Summary
The study found significant reductions in weight, BMI, abdominal circumference, and glycated hemoglobin (A1C) after the VLCKD intervention, with no serious adverse events reported. No significant changes were observed in uric acid, transaminases, urea, or creatinine levels.
Population
11 participants who underwent RYGB without achieving a 50% reduction in excess body weight or who experienced weight regain post-surgery.
Effective Dosage
600-800 kcal/day, low in carbohydrates and lipids (Pnk® method).
Duration
Not specified in the abstract.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
very low-calorie ketogenic diet (VLCKD) (Pnk® method) | decrease | weight | patients who underwent Roux-en-Y gastric bypass (RYGB) without a reduction of 50% in body weight excess or any weight regain after the surgery | - | A significant reduction was observed | #1 |
very low-calorie ketogenic diet (VLCKD) (Pnk® method) | decrease | body mass index (BMI) | patients who underwent Roux-en-Y gastric bypass (RYGB) without a reduction of 50% in body weight excess or any weight regain after the surgery | - | A significant reduction was observed | #2 |
very low-calorie ketogenic diet (VLCKD) (Pnk® method) | decrease | abdominal circumference (AC) | patients who underwent Roux-en-Y gastric bypass (RYGB) without a reduction of 50% in body weight excess or any weight regain after the surgery | - | A significant reduction was observed | #3 |
very low-calorie ketogenic diet (VLCKD) (Pnk® method) | decrease | glycated hemoglobin (A1C) | patients who underwent Roux-en-Y gastric bypass (RYGB) without a reduction of 50% in body weight excess or any weight regain after the surgery | - | A significant reduction was observed | #4 |
very low-calorie ketogenic diet (VLCKD) (Pnk® method) | no change | uric acid | patients who underwent Roux-en-Y gastric bypass (RYGB) without a reduction of 50% in body weight excess or any weight regain after the surgery | - | did not show differences | #5 |
very low-calorie ketogenic diet (VLCKD) (Pnk® method) | no change | transaminases | patients who underwent Roux-en-Y gastric bypass (RYGB) without a reduction of 50% in body weight excess or any weight regain after the surgery | - | did not show differences | #6 |
very low-calorie ketogenic diet (VLCKD) (Pnk® method) | no change | urea | patients who underwent Roux-en-Y gastric bypass (RYGB) without a reduction of 50% in body weight excess or any weight regain after the surgery | - | did not show differences | #7 |
very low-calorie ketogenic diet (VLCKD) (Pnk® method) | no change | creatinine | patients who underwent Roux-en-Y gastric bypass (RYGB) without a reduction of 50% in body weight excess or any weight regain after the surgery | - | did not show differences | #8 |
very low-calorie ketogenic diet (VLCKD) (Pnk® method) | no change | safety | patients who underwent Roux-en-Y gastric bypass (RYGB) without a reduction of 50% in body weight excess or any weight regain after the surgery | - | no serious adverse events were reported | #9 |
PURPOSE: Obesity is one of the major public health problems worldwide and bariatric surgery is considered the gold standard treatment for severe obesity. Although the literature supports the safety and efficacy of the very low-calorie ketogenic diet (VLCKD) in patients with obesity, there is no study analyzing the use in case of failure or weight regain after bariatric surgery. This work has the purpose of assessing the response to a VLCKD (Pnk® method) in this population. METHODS: We have conducted an observational, retrospective, and descriptive study with the analysis of medical charts of private offices where patients were examined between 2014 and 2019, totalizing 11 participants who underwent Roux-en-Y gastric bypass (RYGB) without a reduction of 50% in body weight excess or any weight regain after the surgery. The patients followed the first stage of a commercial weight loss program (Pnk® method) which consists of a VLCKD (600-800 kcal/day), low in carbohydrates and lipids. RESULTS: A significant reduction was observed (p-value < 0.05) in weight, body mass index (BMI), abdominal circumference (AC), and glycated hemoglobin (A1C) post-ketogenic diet. Uric acid, transaminases, urea, and creatinine values did not show differences between pre- and post-ketosis. During the course of the study, no serious adverse events were reported. CONCLUSION: This study has shown that the ketogenic diet can be recommended as an effective and safe treatment for patients who progressed with insufficient weight loss or regain after bariatric surgery.