Interactions between caveolin 1 polymorphism and the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) diet on metabolic dyslipidemia in overweight and obese adult women: a cross-sectional study.
Study Goal
The researchers aimed to investigate the interactions between CAV1 polymorphism and the MIND diet on metabolic dyslipidemia in overweight and obese patients.
Results Summary
The study found a significant interaction between the MIND diet and CAV1 rs3807992, where subjects with dominant alleles had a lower risk of dyslipidemia. Higher adherence to the MIND diet was associated with reduced dyslipidemia in risk allele carriers.
Population
Overweight and obese patients
Effective Dosage
Not available
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
MIND diet | increase | overall health | - | - | had a positive effect | #1 |
MIND diet | decrease | dyslipidemia | overweight and obese patients | β = - 0.25 ± 132 | significant interaction | #2 |
MIND diet | decrease | dyslipidemia | subjects with dominant alleles | - | lower risk | #3 |
MIND diet | decrease | dyslipidemia | risk allele carriers with higher adherence | - | may exhibit the lower | #4 |
MIND diet | increase | dyslipidemia | - | - | may help in improving | #5 |
OBJECTIVE: The increased prevalence of metabolic dyslipidemia (MD) and its association with a variety of disorders raised a lot of attention to its management. Caveolin 1 (CAV1) the key protein in the caval structure of plasma membranes is many cell types that play an important role in its function. (CAV1) is a known gene associated with obesity. Today, a novel diet recognized as the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND) is reported to have a positive effect on overall health. Hence, we aimed to investigate the interactions between CAV1 polymorphism and MIND diet on the MD in overweight and obese patients. RESULTS: Remarkably, there was a significant interaction between the MIND diet and CAV1 rs3807992 for dyslipidemia (β = - 0.25 ± 132, P = 0.05) in the crude model. Whereby, subjects with dominant alleles had a lower risk of dyslipidemia and risk allele carriers with higher adherence to the MIND diet may exhibit the lower dyslipidemia. This study presented the CAV1 gene as a possible genetic marker in recognizing people at higher risks for metabolic diseases. It also indicated that using the MIND diet may help in improving dyslipidemia through providing a probable interaction with CAV1 rs3807992 polymorphism.