The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study.
Study Goal
The researchers aimed to determine whether Vitamin D supplementation could improve glycemic control, insulin resistance, and cardiovascular risk markers in patients with type 2 diabetes mellitus (T2DM) on standard metformin therapy.
Results Summary
The study monitored potential benefits of Vitamin D supplementation on glycemia, HbA1c, insulin resistance (HOMA-IR), and lipid risk indices (Castelli Risk Index I and Triglycerides/Thiobarbituric acid), suggesting possible positive effects, though specific outcomes are not detailed in the abstract.
Population
Patients with type 2 diabetes mellitus (T2DM) on standard metformin therapy (n=130).
Effective Dosage
Not specified in the abstract.
Duration
Not specified in the abstract.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Vitamin D | neutral | pancreatic insulin secretion | - | - | may alter | #1 |
Vitamin D | neutral | peripheral insulin resistance | - | - | may alter | #2 |
Vitamin D | neutral | persistence of systemic 'sterile' inflammation | - | - | may alter | #3 |
Vitamin D | neutral | immune activation | - | - | may alter | #4 |
Vitamin D | neutral | antioxidant effect | - | - | may have | #5 |
Vitamin D supplementation | neutral | glycemia level | patients with T2DM on standard metformin therapy | - | monitored through the influence on | #6 |
Vitamin D supplementation | neutral | glycated haemoglobin (HbA1c) | patients with T2DM on standard metformin therapy | - | monitored through the influence on | #7 |
Vitamin D supplementation | neutral | insulin resistance index (calculated as homeostatic model assessment; HOMA-IR) | patients with T2DM on standard metformin therapy | - | monitored through the influence on | #8 |
Vitamin D supplementation | neutral | Castelli Risk Index I | patients with T2DM on standard metformin therapy | - | monitored through the influence on | #9 |
Vitamin D supplementation | neutral | Tryglicerides/Thiobarbituric acid | patients with T2DM on standard metformin therapy | - | monitored through the influence on | #10 |
Vitamin D deficiency could play an important role in the pathogenesis of type 2 diabetes mellitus (T2DM) as it may alter several crucial processes in the development of diabetes and its complications, such as pancreatic insulin secretion, peripheral insulin resistance, persistence of systemic "sterile" inflammation and immune activation. Vitamin D may also have an antioxidant effect through the inhibition of free radicals generation. The reported study was designed with eligible consecutively recruited patients with T2DM on standard metformin therapy (n=130), randomized in 1:1 ratio, considered to have undergone Vitamin D supplementation according to the guidelines proposed by the Endocrine Society, or to have continued with metformin only. The potential benefit was monitored through the influence on glycemia level, glycated haemoglobin (HbA1c), insulin resistance index (calculated as homeostatic model assessment; HOMA-IR), Castelli Risk Index I and Tryglicerides/Thiobarbituric acid