Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial.
Study Goal
The researchers aimed to determine the effectiveness of vitamin D and omega-3 co-supplementation on psychological distress in women of reproductive age with pre-diabetes and hypovitaminosis D.
Results Summary
The study found that co-supplementation of vitamin D and omega-3 significantly reduced anxiety, depression, and stress while improving sleep quality compared to placebo or single-supplement groups. The effects were statistically significant (p < .05).
Population
Women of reproductive age with pre-diabetes and hypovitaminosis D.
Effective Dosage
50,000-IU pearls every 2 weeks for vitamin D.
Duration
8 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
omega-3 and vitamin D co-supplementation | decrease | anxiety | women of reproductive age with pre-diabetes and hypovitaminosis D | - | significant difference was observed in terms of reduction | #1 |
omega-3 and vitamin D co-supplementation | increase | sleep quality | women of reproductive age with pre-diabetes and hypovitaminosis D | - | significant difference was observed in terms of improvement | #2 |
omega-3 and vitamin D co-supplementation | decrease | depression | women of reproductive age with pre-diabetes and hypovitaminosis D | - | significant difference in terms of reduction | #3 |
omega-3 and vitamin D co-supplementation | decrease | stress | women of reproductive age with pre-diabetes and hypovitaminosis D | - | significant difference in terms of reduction | #4 |
Vitamin D and omega-3 co-supplementation | increase | depression | women of reproductive age with pre-diabetes and hypovitaminosis D | - | improved | #5 |
Vitamin D and omega-3 co-supplementation | increase | anxiety | women of reproductive age with pre-diabetes and hypovitaminosis D | - | improved | #6 |
Vitamin D and omega-3 co-supplementation | increase | sleep quality | women of reproductive age with pre-diabetes and hypovitaminosis D | - | improved | #7 |
PURPOSE: Psychological distresses and pre-diabetes are among the risk factors of developing type-II diabetes. The present study was conducted to determine the effectiveness of omega-3 and vitamin D co-supplementation on psychological distresses in women of reproductive age with pre-diabetes and hypovitaminosis D. METHODS: The present factorial clinical trial was conducted on 168 women of reproductive age with pre-diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega-3 group), group 3 (vitamin D group), and group 4 (co-supplement group). The medication and placebo doses being two 1000-mg tablets each day for omega-3 and 50,000-IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale-21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention. RESULTS: A significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co-supplementation compared to the other three groups (p < .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (p < .05). CONCLUSION: Vitamin D and omega-3 co-supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre-diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women. CLINICAL TRIAL REGISTRY: Iranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.