Nutraceuticals in the Mediterranean Diet: Potential Avenues for Breast Cancer Treatment.
Study Goal
The researchers aimed to summarize the anticancer mechanisms of Epigallocatechin Gallate (EGCG) and other bioactive compounds in the context of breast cancer.
Results Summary
The study found that EGCG exhibits anticancer properties by modulating cell cycle arrest, apoptosis, inflammation, and angiogenesis, supported by in vitro and in vivo evidence. It highlights EGCG's potential as a future therapeutic candidate for breast cancer.
Population
Not specified (review of in vitro and in vivo studies).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Mediterranean-style diet | decrease | chronic illnesses, such as cardiovascular and neurodegenerative diseases and cancer including breast carcinoma | population living in countries bordering the Mediterranean Sea | - | provides several dietary compounds that have been reported to exert beneficial biological effects | #1 |
natural polyphenols, retinoids, and polyunsaturated fatty acids (PUFAs) | increase | antioxidant, anti-inflammatory, immunomodulatory and antitumoral properties | - | - | have been reported to possess | #2 |
natural polyphenols, retinoids, and polyunsaturated fatty acids (PUFAs) | decrease | breast cancer | - | - | identified as protective factors for | #3 |
some polyphenols, like resveratrol and epigallocatechin 3-gallate, retinoids and omega-3 PUFAs | increase | cell cycle growth arrest | - | - | anticancer action | #4 |
some polyphenols, like resveratrol and epigallocatechin 3-gallate, retinoids and omega-3 PUFAs | increase | apoptosis | - | - | anticancer action | #5 |
some polyphenols, like resveratrol and epigallocatechin 3-gallate, retinoids and omega-3 PUFAs | decrease | inflammation | - | - | anticancer action | #6 |
some polyphenols, like resveratrol and epigallocatechin 3-gallate, retinoids and omega-3 PUFAs | decrease | angiogenesis | - | - | anticancer action | #7 |
these natural compounds | decrease | breast cancer disease | - | - | could be the prospective candidates for the future anticancer therapeutics | #8 |
The traditional Mediterranean Diet constitutes a food model that refers to the dietary patterns of the population living in countries bordering the Mediterranean Sea in the early 1960s. A huge volume of literature data suggests that the Mediterranean-style diet provides several dietary compounds that have been reported to exert beneficial biological effects against a wide spectrum of chronic illnesses, such as cardiovascular and neurodegenerative diseases and cancer including breast carcinoma. Among bioactive nutrients identified as protective factors for breast cancer, natural polyphenols, retinoids, and polyunsaturated fatty acids (PUFAs) have been reported to possess antioxidant, anti-inflammatory, immunomodulatory and antitumoral properties. The multiple anticancer mechanisms involved include the modulation of molecular events and signaling pathways associated with cell survival, proliferation, differentiation, migration, angiogenesis, antioxidant enzymes and immune responses. This review summarizes the anticancer action of some polyphenols, like resveratrol and epigallocatechin 3-gallate, retinoids and omega-3 PUFAs by highlighting the important hallmarks of cancer in terms of (i) cell cycle growth arrest, (ii) apoptosis, (iii) inflammation and (iv) angiogenesis. The data collected from in vitro and in vivo studies strongly indicate that these natural compounds could be the prospective candidates for the future anticancer therapeutics in breast cancer disease.