Metabolic Profiling of Plasma in Patients with Irritable Bowel Syndrome after a 4-Week Starch- and Sucrose-Reduced Diet.
Study Goal
The researchers aimed to examine the metabolic profile and gastrointestinal symptom changes in IBS patients following a starch- and sucrose-restricted diet (SSRD).
Results Summary
SSRD led to significant metabolic changes, particularly in linoleic acid metabolism and fatty acid biosynthesis, and markedly reduced gastrointestinal symptoms, though these improvements did not correlate with metabolic changes.
Population
Patients with irritable bowel syndrome (IBS) (n = 69 intervention, n = 22 control).
Effective Dosage
Not specified
Duration
4 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
starch- and sucrose-restricted diet (SSRD) | increase | circulating metabolite concentrations | patients with irritable bowel syndrome (IBS) | marked changes | led to marked changes | #1 |
starch- and sucrose-restricted diet (SSRD) | decrease | starch intake | patients with irritable bowel syndrome (IBS) | - | reduced | #2 |
starch- and sucrose-restricted diet (SSRD) | increase | polyunsaturated fat intake | patients with irritable bowel syndrome (IBS) | - | increased | #3 |
starch- and sucrose-restricted diet (SSRD) | decrease | gastrointestinal symptoms | patients with irritable bowel syndrome (IBS) | marked reduction | marked reduction | #4 |
starch- and sucrose-restricted diet (SSRD) | increase | linoleic acid metabolism | patients with irritable bowel syndrome (IBS) | clear metabolic effects | was observed by clear metabolic effects | #5 |
starch- and sucrose-restricted diet (SSRD) | increase | fatty acid biosynthesis | patients with irritable bowel syndrome (IBS) | clear metabolic effects | was observed by clear metabolic effects | #6 |
starch- and sucrose-restricted diet (SSRD) | increase | beta-oxidation | patients with irritable bowel syndrome (IBS) | clear metabolic effects | was observed by clear metabolic effects | #7 |
A 4-week dietary intervention with a starch- and sucrose-restricted diet (SSRD) was conducted in patients with irritable bowel syndrome (IBS) to examine the metabolic profile in relation to nutrient intake and gastrointestinal symptoms. IBS patients were randomized to SSRD intervention (n = 69) or control continuing with their ordinary food habits (n = 22). Food intake was registered and the questionnaires IBS-symptoms severity scale (IBS-SSS) and visual analog scale for IBS (VAS-IBS) were completed. Metabolomics untargeted analysis was performed by gas chromatography mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS) in positive and negative ionization modes. SSRD led to marked changes in circulating metabolite concentrations at the group level, most prominent for reduced starch intake and increased polyunsaturated fat, with small changes in the control group. On an individual level, the correlations were weak. The marked reduction in gastrointestinal symptoms did not correlate with the metabolic changes. SSRD was observed by clear metabolic effects mainly related to linoleic acid metabolism, fatty acid biosynthesis, and beta-oxidation.