Effect of vitamin D supplementation on markers of cardiometabolic risk in children and adolescents: A meta-analysis of randomized clinical trials.
Study Goal
The researchers aimed to determine the effect of vitamin D supplementation on cardiometabolic risk markers in children and adolescents.
Results Summary
Vitamin D supplementation did not significantly affect most cardiometabolic risk markers (HDL-C, LDL-C, TC, BMI, waist circumference, blood pressure) but showed a beneficial effect on fasting glucose and triglycerides at high doses (≥200,000 IU total).
Population
Children and adolescents
Effective Dosage
Total vitamin D supplementation ≥200,000 IU (subgroup analysis)
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
vitamin D supplementation | no change | high-density lipoprotein-cholesterol (HDL-C) | children and adolescents | no significant change | did not affect the changes of | #1 |
vitamin D supplementation | no change | low-density lipoprotein cholesterol (LDL-C) | children and adolescents | no significant change | did not affect the changes of | #2 |
vitamin D supplementation | no change | total cholesterol (TC) | children and adolescents | no significant change | did not affect the changes of | #3 |
vitamin D supplementation | no change | triglycerides (TG) | children and adolescents | no significant change | did not affect the changes of | #4 |
vitamin D supplementation | no change | body mass index (BMI) | children and adolescents | no significant change | did not affect the changes of | #5 |
vitamin D supplementation | no change | waist circumferences | children and adolescents | no significant change | did not affect the changes of | #6 |
vitamin D supplementation | no change | systolic blood pressure (SDP) | children and adolescents | no significant change | did not affect the changes of | #7 |
vitamin D supplementation | no change | diastolic blood pressure (DBP) | children and adolescents | no significant change | did not affect the changes of | #8 |
vitamin D supplementation | decrease | fasting glucose | children and adolescents | MD, -1.54 mg/dl, 95% CI -2.98 to -0.10 | showed a beneficial effect on | #9 |
vitamin D supplementation | decrease | TG | children and adolescents | MD, -24.76 mg/dl, 95% CI -37.66 to -11.86 | showed a beneficial effect on | #10 |
BACKGROUND AND AIMS: An increasing attention to the effect of vitamin D supplementation on cardiometabolic risk markers in children and adolescents has been gained recently. However, the results are inconsistent. Therefore, we conducted a meta-analysis to examine the effect of vitamin D supplementation on cardiometabolic risk markers in children and adolescents. METHODS AND RESULTS: Eligible randomized controlled trials (RCTs) were identified by searching PubMed, EMBASE and Web of Science. The results of this study are synthetized and reported in accordance with the PRISMA statement. GRADE system was used to assess the certainty of evidence. A total of 9 RCTs were identified and included in the meta-analysis. We found that vitamin D supplementation did not affect the changes of cardiometabolic risk markers including high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), body mass index (BMI), waist circumferences, systolic blood pressure (SDP) and diastolic blood pressure (DBP). However, vitamin D supplementation showed a beneficial effect on fasting glucose (MD, -1.54 mg/dl, 95% CI -2.98 to -0.10) and TG (MD, -24.76 mg/dl, 95% CI -37.66 to -11.86) in the sub-group analysis of total vitamin D supplementation ≥ 200,000 IU. CONCLUSIONS: Vitamin D supplementation appeared to have a beneficial effect on reducing fasting glucose and TG level when total vitamin D supplementation ≥200,000 IU but not HDL-C, LDL-C TC, blood pressure and waist circumferences levels in children and adolescents. Further studies are needed to address this issue.