The effects of the dietary approaches to stop hypertension (DASH) diet on oxidative stress and clinical indices of migraine patients: a randomized controlled trial.
Study Goal
The researchers aimed to investigate the relationship between the DASH diet and oxidative stress in women diagnosed with migraine, as well as its effects on migraine clinical indices.
Results Summary
The DASH diet significantly reduced nitric oxide (NO) and total oxidative status (TOS), and marginally reduced oxidative stress index (OSI) compared to the control group. It also significantly improved migraine indices (MI, HDR, MHIS), but showed no significant changes in total antioxidant capacity (TAC), malondialdehyde (MDA), or total thiol content.
Population
102 women diagnosed with migraine.
Effective Dosage
Not specified (dietary intervention).
Duration
3 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
DASH diet | decrease | nitric oxide (NO) | women diagnosed with migraine | -5.75 vs. +4.18 | significant reduction | #1 |
DASH diet | decrease | total oxidative status (TOS) | women diagnosed with migraine | -1.55 vs. +0.71 | significant reduction | #2 |
DASH diet | decrease | oxidative stress index (OSI) | women diagnosed with migraine | -0.10 vs. +0.14 | marginally significant reduction | #3 |
DASH diet | decrease | migraine index (MI) | women diagnosed with migraine | -31.33 vs. -15.09 | significant decrease | #4 |
DASH diet | decrease | headache dairy result (HDR) | women diagnosed with migraine | -5.04 vs. -2.51 | significant decrease | #5 |
DASH diet | decrease | migraine headache index score (MHIS) | women diagnosed with migraine | -44.21 vs. -26.74 | significant decrease | #6 |
DASH diet | no change | total antioxidant capacity (TAC) | women diagnosed with migraine | - | no significant change | #7 |
DASH diet | no change | malondialdehyde (MDA) | women diagnosed with migraine | - | no significant change | #8 |
DASH diet | no change | total thiol content | women diagnosed with migraine | - | no significant change | #9 |
AIMS: The relationship between the Dietary Approaches to Stop Hypertension (DASH) diet and oxidative stress (OS) in patients diagnosed with migraine is unknown and remains to be examined. Hence, we conducted a parallel-group, randomized controlled trial to investigate this issue. METHODS: Of the 102 women who met all the inclusion criteria, 51 individuals were randomized to the DASH diet group and 51 to the usual dietary advice group to receive allocated intervention for three months. In order to assess the compliance of participants to the DASH diet, dietary records, and serum vitamin C levels were examined. Parameters of OS status (e.g. nitric oxide (NO), total antioxidant capacity (TAC), total oxidative status (TOS), malondialdehyde (MDA), and oxidative stress index (OSI)) and clinical indices of migraine (e.g. migraine index (MI), headache dairy result (HDR), and migraine headache index score (MHIS)) were assessed at the beginning and the end of the study. RESULTS: There was a significant reduction in NO (-5.75 vs. + 4.18, P = 0.025) and TOS (-1.55 vs. + 0.71, P = 0.034), and a marginally significant reduction in OSI (-0.10 vs. + 0.14, P = 0.060) in the DASH group compared with the control. Compliance with the DASH diet resulted in a significant decrease in the score of MI (-31.33 vs. - 15.09), HDR (-5.04 vs. -2.51), and MHIS (-44.21 vs. -26.74). Moreover, no significant change was observed in TAC, MDA, and total thiol content. CONCLUSION: This type of dietary approach can be considered as a complementary treatment for migraine patients, also further investigations are needed to replicate our findings.Trial registration: Iranian Registry of Clinical Trials identifier: IRCT20121216011763N38.