Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota.
Study Goal
The researchers aimed to determine whether short-term Western diet intake exacerbates IL-23-mediated skin and joint inflammation and alters gut microbiota in mice.
Results Summary
The study found that Western diet worsened IL-23-mediated psoriasis and psoriatic arthritis, increased IL-17A-expressing γδ T cells, and altered gut microbiota. These effects were mitigated by dietary changes or antibiotics.
Population
Mice
Effective Dosage
Not specified
Duration
Short-term (exact duration not specified)
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Western diet (WD) | increase | an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis | mice | - | exacerbates | #1 |
Western diet (WD) | increase | IL-23-mediated skin and joint inflammation | mice | - | promotes | #2 |
Western diet (WD) | increase | the gut microbiota | mice | - | accompanied by changes to | #3 |
Western diet (WD) | increase | IL-17A‒expressing γδ T cells | mice | - | expansion of | #4 |
Western diet (WD) | increase | the gut microbial community | mice | - | shifts to | #5 |
diet manipulation | decrease | WD-associated inflammation | mice | - | mitigated | #6 |
antibiotic administration | decrease | WD-associated inflammation | mice | - | mitigated | #7 |
Shi et al. (2021) in "Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice" show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒expressing γδ T cells and shifts to the gut microbial community. WD-associated inflammation is mitigated by diet manipulation or antibiotic administration. These results suggest that dietary manipulation may be useful in the treatment of IL-23‒mediated disease, possibly through the modulation of the gut microbiota.