Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study.
Study Goal
The researchers aimed to determine whether chronic Capsiate supplementation combined with resistance training improves muscular adaptations, inflammatory response, and performance in untrained men.
Results Summary
Chronic Capsiate supplementation increased fat-free mass and upper body strength but had no effect on lower body strength or inflammatory response. The majority of the fat-free mass increase was due to increased total body water.
Population
Untrained young men
Effective Dosage
12 mg Capsiate daily
Duration
6 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Exercise and CAP supplementation | increase | fat-free mass | untrained men | 1.5 kg | increased | #1 |
CAP supplementation | increase | fat-free mass | untrained men | CAP ∆%= 2.1 ± 1.8 %, PLA ∆%= 0.7 ± 1.3 % | change scores for fat-free mass were significantly greater | #2 |
CAP supplementation | increase | upper body strength | untrained men | CAP ∆%= 13.4 ± 9.1 %, PLA ∆%= 5.8 ± 5.2 % | greater upper body strength change score | #3 |
CAP supplementation | no change | lower body strength | untrained men | - | had no effect | #4 |
CAP supplementation | no change | all cytokines in response to acute resistance exercise | untrained men | - | no supplementation interactions were observed | #5 |
Chronic Capsiate supplementation combined with resistance training | increase | fat-free mass and upper body strength | young untrained men | - | increased | #6 |
Chronic Capsiate supplementation combined with resistance training | no change | inflammatory response and performance | young untrained men | - | not | #7 |
BACKGROUND: Acute capsaicinoid and capsinoid supplementation has endurance and resistance exercise benefits; however, if these short-term performance benefits translate into chronic benefits when combined with resistance training is currently unknown. This study investigated changes of chronic Capsiate supplementation on muscular adaptations, inflammatory response and performance in untrained men. METHODS: Twenty untrained men were randomized to ingest 12 mg Capsiate (CAP) or placebo in a parallel, double-blind design. Body composition and performance were measured at pre-training and after 6 weeks of resistance training. An acute resistance exercise session test was performed pre and post-intervention. Blood samples were collected at rest and post-resistance exercise to analyze Tumor necrosis factor- (TNF-), Soluble TNF- receptor (sTNF-r), Interleukin-6 (IL-6) and Interleukin-10 (IL-10). RESULTS: Exercise and CAP supplementation increased fat-free mass in comparison to baseline by 1.5 kg (P < 0.001), however, the majority of the increase (1.0 kg) resulted from an increase in total body water. The CAP change scores for fat-free mass were significantly greater in comparison to the placebo (CAP ∆%= 2.1 ± 1.8 %, PLA ∆%= 0.7 ± 1.3 %, P = 0.043) and there was a significant difference between groups in the bench press exercise (P = 0.034) with greater upper body strength change score for CAP (∆%= 13.4 ± 9.1 %) compared to placebo (∆%= 5.8 ± 5.2 %), P = 0.041. CAP had no effect on lower body strength and no supplementation interactions were observed for all cytokines in response to acute resistance exercise (P > 0.05). CONCLUSION: Chronic Capsiate supplementation combined with resistance training during short period (6 weeks) increased fat-free mass and upper body strength but not inflammatory response and performance in young untrained men.