Amelioration of inflammation in young men with cardiovascular risks participating pedometer-based walking programme.
Study Goal
The researchers aimed to evaluate whether a pedometer-based walking program could reduce inflammation markers (CRP, IL-6, TNF-α) and improve cardiovascular health in sedentary young men with risk factors.
Results Summary
The pedometer group significantly increased daily steps (from ~5,000 to ~10,000) and showed reduced inflammation markers (CRP, IL-6, TNF-α) and improved lipid profiles, while the control group showed no changes.
Population
Sedentary young men (20-40 years) with ≥2 cardiovascular risk factors and <5,000 daily steps.
Effective Dosage
Minimum target of 8,000 steps/day.
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
pedometer-based walking programme | increase | step count | young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors | from 4996 ± 805 to 10,128 ±511 steps/day | significant increased | #1 |
pedometer-based walking programme | increase | anthropometric variables | young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors | - | significant improvement | #2 |
pedometer-based walking programme | increase | lipid | young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors | - | significant improvement | #3 |
pedometer-based walking programme | decrease | C-Reactive protein (CRP) | young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors | - | significantly reduced | #4 |
pedometer-based walking programme | decrease | interleukin-6 (IL-6) | young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors | - | significantly reduced | #5 |
pedometer-based walking programme | decrease | tumour necrosis factor-alpha (TNF-α) | young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors | - | significantly reduced | #6 |
pedometer-based walking programme | decrease | inflammation | young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors | - | improved | #7 |
pedometer-based walking programme | decrease | arterial stiffness | young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors | - | improved | #8 |
control group (no change in walking) | no change | C-Reactive protein (CRP), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) | young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors | - | no changes were seen | #9 |
INTRODUCTION: Inflammation plays a central role in the pathogenesis of cardiovascular events. The lack of exercise among Malaysians and the increasing cardiovascular diseases among young men are of concern. The aim of this study was to evaluate the reducing of inflammation by measuring C-Reactive protein (CRP), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α). MATERIALS AND METHODS: A total of 70 young men (20 - 40 years) who were sedentary, achieving less than 5,000 steps/day in casual walking with 2 or more cardiovascular risk factors were recruited in Institute of Vocational Skills for Youth (IKBN Hulu Langat). Subjects were randomly assigned to a control group (CG) (n=34; no change in walking) and pedometer group (PG) (n=36; minimum target: 8,000 steps/day). All parameter was measured at baseline, at 6 weeks and after 12 weeks. RESULTS: At post intervention, the CG step counts were similar (4983 ± 366vs 5697 ± 407steps/day). The PG significant increased step count from 4996 ± 805 to 10,128 ±511 steps/day (p<0.001). The PG showed significant improvement in anthropometric variables and lipid (time and group effect p<0.001). After intervention, CRP, IL-6 and TNF- α were significantly reduced for time and group effect (p<0.001). However, no changes were seen in CG. CONCLUSION: The pedometer-based walking programme improved health status in terms of improving inflammation and arterial stiffness.