Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.
Study Goal
The researchers aimed to review the biological effects and translational potential of Urolithin A as a nutritional intervention for aging and age-related conditions.
Results Summary
Urolithin A enhances cellular health by promoting mitophagy, improving mitochondrial function, and reducing inflammation. Preclinical and clinical studies suggest it protects against aging-related conditions in muscles, brain, and joints, with clinical trials supporting benefits in elderly muscle health.
Population
Elderly people (clinical trials), preclinical models (animal/cellular studies).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Urolithin A (UA) | increase | cellular health | - | - | enhances | #1 |
Urolithin A (UA) | increase | mitophagy | - | - | increasing | #2 |
Urolithin A (UA) | increase | mitochondrial function | - | - | increasing | #3 |
Urolithin A (UA) | decrease | detrimental inflammation | - | - | reducing | #4 |
Urolithin A (UA) | decrease | aging and age-related conditions affecting muscle, brain, joints, and other organs | - | - | protects against | #5 |
UA supplementation | increase | muscle | elderly people | - | benefits | #6 |
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its impact on aging and disease been explored. UA enhances cellular health by increasing mitophagy and mitochondrial function and reducing detrimental inflammation. Several preclinical studies show how UA protects against aging and age-related conditions affecting muscle, brain, joints, and other organs. In humans, benefits of UA supplementation in the muscle are supported by recent clinical trials in elderly people. Here, we review the state of the art of UA's biology and its translational potential as a nutritional intervention in humans.