Ketogenic Diet Suppressed T-Regulatory Cells and Promoted Cardiac Fibrosis via Reducing Mitochondria-Associated Membranes and Inhibiting Mitochondrial Function.
Oxidative medicine and cellular longevity
January 1, 2021
Jun Tao et al. (12 authors)
Journal ArticleHuman StudyAnimal Study
Extracted Claims (11)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Ketogenic diet (KD) | neutral | cardiac function | diabetic cardiomyopathy (DCM) | - | effects and the underlined mechanisms | #1 |
Ketogenic diet (KD) | neutral | cardiac safety | diabetic patients | - | effects and the underlined mechanisms | #2 |
Ketogenic diet (KD) | neutral | cardiac efficiency | diabetic patients | - | effects and the underlined mechanisms | #3 |
different diets (regular or KD) | neutral | cardiac function | db/db mice | - | determined | #4 |
different diets (regular or KD) | neutral | interstitial fibrosis | db/db mice | - | determined | #5 |
different diets (regular or KD) | neutral | T-regulatory cell (Treg) number | db/db mice | - | evaluated | #6 |
different diets (regular or KD) | neutral | T-regulatory cell (Treg) functions | db/db mice | - | evaluated | #7 |
ketone body (KB) | neutral | fatty acid (FA) metabolism | - | - | assessed | #8 |
ketone body (KB) | neutral | glucose metabolism | - | - | assessed | #9 |
ketone body (KB) | neutral | mitochondria-associated endoplasmic reticulum membranes (MAMs) | - | - | assessed | #10 |
ketone body (KB) | neutral | mitochondrial respiration | - | - | assessed | #11 |
Abstract
Ketogenic diet (KD) is popular in diabetic patients but its cardiac safety and efficiency on the heart are unknown. The aim of the present study is to determine the effects and the underlined mechanisms of KD on cardiac function in diabetic cardiomyopathy (DCM). We used db/db mice to model DCM, and different diets (regular or KD) were used. Cardiac function and interstitial fibrosis were determined. T-regulatory cell (Treg) number and functions were evaluated. The effects of ketone body (KB) on fatty acid (FA) and glucose metabolism, mitochondria-associated endoplasmic reticulum membranes (MAMs), and mitochondrial respiration were assessed. The mechanisms
Medical Subject Headings (MeSH)
AnimalsCardiovascular DiseasesDiet, KetogenicFibrosisHumansMaleMiceMitochondriaT-Lymphocytes, Regulatory
Study Links
PubMed ID33959215
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