Efficacy of Low-Carbohydrate Ketogenic Diet as an Adjuvant Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Study Goal
The researchers aimed to investigate the efficacy of a low-carbohydrate ketogenic diet (LCKD) as an adjuvant therapy in antitumor treatment compared to non-ketogenic diets, focusing on lipid profile, body weight, fasting glucose, insulin, and adverse effects.
Results Summary
The study conducted a meta-analysis of RCTs but did not provide specific findings in the abstract regarding the efficacy of LCKD in antitumor treatment or its effects on the measured parameters.
Population
Cancer participants in randomized controlled trials.
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
low-carbohydrate ketogenic diet (LCKD) | neutral | lipid profile | cancer participants | - | investigate the efficacy | #1 |
low-carbohydrate ketogenic diet (LCKD) | neutral | body weight | cancer participants | - | investigate the efficacy | #2 |
low-carbohydrate ketogenic diet (LCKD) | neutral | fasting glucose level | cancer participants | - | investigate the efficacy | #3 |
low-carbohydrate ketogenic diet (LCKD) | neutral | insulin | cancer participants | - | investigate the efficacy | #4 |
low-carbohydrate ketogenic diet (LCKD) | neutral | adverse effects | cancer participants | - | investigate the efficacy | #5 |
The role of low-carbohydrate ketogenic diet (LCKD) as an adjuvant therapy in antitumor treatment is not well established. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate the efficacy of LCKD as an adjuvant therapy in antitumor treatment compared to non-ketogenic diet in terms of lipid profile, body weight, fasting glucose level, insulin, and adverse effects; Methods: In this study, databases such as PubMed, Web of Science, Scopus, CINAHL, and Cochrane trials were searched. Only RCTs that involved cancer participants that were assigned to dietary interventions including a LCKD group and a control group (any non-ketogenic dietary intervention) were selected. Three reviewers independently extracted the data, and the meta-analysis was performed using a fixed effects model or random effects model depending on the I