Portable NIV for patients with moderate to severe COPD: two randomized crossover trials.
Study Goal
The researchers aimed to determine whether portable non-invasive ventilation (pNIV) during walking improves dyspnea and endurance capacity in patients with moderate to severe COPD.
Results Summary
The study found that pNIV use during walking improved dyspnea and walking distance in COPD patients, with greater benefits observed in those not already receiving long-term NIV therapy.
Population
Patients with moderate to severe COPD (mean age 66.9 ± 7.4 years).
Effective Dosage
Pre-set inspiratory/expiratory positive airway pressure of 18/8 cmH₂O.
Duration
Not specified (crossover trials with standardized 6-minute walking tests).
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Long-term non-invasive ventilation (NIV) | neutral | chronic hypercapnic COPD | COPD patients | - | established treatment option | #1 |
Long-term non-invasive ventilation (NIV) | increase | exercise | chronic hypercapnic COPD patients | - | Beneficial effects have also been shown | #2 |
portable NIV (pNIV) devices | increase | walking at home | - | - | may now enable NIV application | #3 |
pNIV | neutral | dyspnea and endurance capacity | patients with moderate to severe COPD | - | impact | #4 |
pNIV | decrease | dyspnea | patients with moderate to severe COPD | - | improved | #5 |
pNIV | increase | walking distance | patients with moderate to severe COPD | - | improved | #6 |
pNIV device during walking | increase | dyspnea and walking distance | patients with moderate to severe COPD | - | can improve | #7 |
pNIV | increase | - | Patients who do not already receive long-term NIV therapy | - | more likely to benefit | #8 |
BACKGROUND: Long-term non-invasive ventilation (NIV) is as an established treatment option for chronic hypercapnic COPD patients. Beneficial effects have also been shown during exercise, but this is restricted to rehabilitation programs. New portable NIV (pNIV) devices may now enable NIV application during walking at home. STUDY DESIGN AND METHODS: In two randomized crossover trials, the impact of pNIV on dyspnea and endurance capacity was investigated in patients with moderate to severe COPD. Participants performed a standardized 6-min walking test, with and without pNIV, using a pre-set inspiratory/expiratory positive airway pressure of 18/8 cmH RESULTS: 38 patients (66.9 ± 7.4 years, mean FEV INTERPRETATION: The use of a pNIV device during walking can improve dyspnea and walking distance in patients with moderate to severe COPD. Patients who do not already receive long-term NIV therapy are more likely to benefit compared to those undergoing long-term NIV. Careful patient selection is mandatory. Clinical Trial Register: DRKS00013203; DRKS00012913 registered October 20th 2017 and October 16th 2017; https://www.drks.de/drks_web/.