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Vitamin D

Journal of cachexia, sarcopenia and muscle
June 1, 2021
Knut Sindre Mølmen et al. (18 authors)
Journal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov'tHuman StudyClinical
Study Details

Study Goal

The researchers aimed to investigate the effects of vitamin D supplementation on responses to resistance training, particularly in older adults and individuals with chronic diseases like COPD.

Results Summary

Resistance training over 13 weeks increased muscle strength (13%), muscle mass (9%), and endurance performance (23% for one-legged, 8% for whole-body), while also reducing visceral fat (-6%) and LDL levels. The abstract does not provide conclusive results on the impact of vitamin D supplementation.

Population

95 male and female participants (68 ± 5 years), including healthy individuals (n=71) and those with COPD (n=24).

Effective Dosage

Not specified in the abstract.

Duration

13 weeks.

Interactions

None mentioned.

Extracted Claims (5)
InterventionDirectionEndpointPopulationDosageImpactClaim #
resistance training
increase
muscle strength
male and female participants (healthy, n = 71; COPD, n = 24; age 68 ± 5 years)
13% ± 8%
increased
#1
resistance training
increase
muscle mass
male and female participants (healthy, n = 71; COPD, n = 24; age 68 ± 5 years)
9% ± 8%
increased
#2
resistance training
increase
endurance performance (one-legged)
male and female participants (healthy, n = 71; COPD, n = 24; age 68 ± 5 years)
23% ± 15%
increased
#3
resistance training
increase
endurance performance (whole-body)
male and female participants (healthy, n = 71; COPD, n = 24; age 68 ± 5 years)
8% ± 7%
increased
#4
resistance training
decrease
visceral fat
male and female participants (healthy, n = 71; COPD, n = 24; age 68 ± 5 years)
-6% ± 21%
associated with changes in
#5
Abstract

BACKGROUND: Lifestyle therapy with resistance training is a potent measure to counteract age-related loss in muscle strength and mass. Unfortunately, many individuals fail to respond in the expected manner. This phenomenon is particularly common among older adults and those with chronic diseases (e.g. chronic obstructive pulmonary disease, COPD) and may involve endocrine variables such as vitamin D. At present, the effects of vitamin D supplementation on responses to resistance training remain largely unexplored. METHODS: Ninety-five male and female participants (healthy, n = 71; COPD, n = 24; age 68 ± 5 years) were randomly assigned to receive either vitamin D RESULTS: Overall, 13 weeks of resistance training increased muscle strength (13% ± 8%), muscle mass (9% ± 8%), and endurance performance (one-legged, 23% ± 15%; whole-body, 8% ± 7%), assessed as weighted combined factors, and were associated with changes in health variables (e.g. visceral fat, -6% ± 21%; [LDL] CONCLUSIONS: Vitamin D

Medical Subject Headings (MeSH)
AgedCholecalciferolDietary SupplementsFemaleHumansMaleMiddle AgedResistance TrainingVitamin DVitamins
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality80/10
Citation Metrics
Total Citations27
Citations/Year6.8
Relative Citation Ratio3.00
NIH Percentile85%
Research Impact Scores
APT Score0.75
Weight Score2.65
Normalized Score0.66
Related Supplements
Vitamin D | Panacea Index