A study protocol for a randomized controlled trial of an anti-inflammatory nutritional intervention in patients with fibromyalgia.
Study Goal
The researchers aimed to determine whether eliminating dairy as part of an anti-inflammatory diet could alleviate symptoms in fibromyalgia patients.
Results Summary
The abstract does not provide specific results regarding dairy's effects, as the study is ongoing and outcomes are yet to be reported.
Population
100 female fibromyalgia patients followed at the Portuguese Institute of Rheumatology.
Effective Dosage
Not specified (dairy was excluded entirely from the intervention group's diet).
Duration
3 months (with a low-FODMAP phase in the first month).
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
anti-inflammatory diet | neutral | disease assessment parameters | fibromyalgia (FM) patients | - | analyze the effects | #1 |
anti-inflammatory diet | neutral | inflammatory markers | fibromyalgia (FM) patients | - | analyze the effects | #2 |
anti-inflammatory diet | neutral | quality of life | fibromyalgia (FM) patients | - | analyze the effects | #3 |
anti-inflammatory diet | decrease | symptoms | fibromyalgia (FM) patients | - | helps to alleviate symptoms | #4 |
anti-inflammatory diet | increase | medical intervention | fibromyalgia (FM) patients | - | would optimize | #5 |
BACKGROUND: This study aims to analyze the effects of a potentially anti-inflammatory nutritional intervention in disease assessment parameters, inflammatory markers, and quality of life of fibromyalgia (FM) patients. METHODS: A sample of 100 female patients diagnosed with FM, followed up at Portuguese Institute of Rheumatology (IPR) in Lisbon, is being randomly allocated in two groups. Patients in the intervention group are adopting an anti-inflammatory diet, characterized by the exemption of the intake of foods containing gluten, dairy, sugar, and ultra-processed foods, during 3 months. During the first month, a low fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) diet is implemented, along with the anti-inflammatory diet, followed by the reintroduction of all fruits and vegetables over a consecutive period of 2 months. Patients in the control group are adopting a diet based on general recommendations for healthy eating. The outcomes are pain, fatigue, quality of sleep, quality of life, gastrointestinal symptoms, and inflammation. Before and after the 3 months intervention, and also 1 month after beginning the intervention, the following questionnaires are applied: Revised Fibromyalgia Impact Questionnaire, visual analog pain scale, Brief Pain Inventory,visual analog scale from a list of common gastrointestinal and extraintestinal symptoms in FM, Short Form 36, Fatigue Severity Survey, and Pittsburg Sleep Quality Index. Ultra-sensitive serum C-reactive protein, eritrocyte sedimentation rate, and interleukin-8 are determined. Age, physical activity, anthropometric parameters, and body composition are being collected. Student's t test will assess the association between the disease evaluation parameters, the inflammatory markers, and the dietary interventions. DISCUSSION: The results of this study are expected to determine whether a change in patient nutrition helps to alleviate symptoms, which would optimize medical intervention. TRIAL REGISTRATION: www.ClinicalTrials.gov NCT04007705 . Registered on July 5, 2019.