Circulating inflammatory markers may mediate the relationship between low carbohydrate diet and circadian rhythm in overweight and obese women.
Study Goal
The researchers aimed to evaluate the association between adherence to a Low-Carbohydrate Diet (LCD) and circadian rhythm mediated by inflammatory markers in overweight and obese women.
Results Summary
The study found a negative correlation between LCD adherence and circadian rhythm disturbance, suggesting LCD may improve circadian rhythm by reducing inflammatory markers like IL-1β and Galectin-3. The relationship was mediated by these markers in intermediate and morning-type groups.
Population
304 overweight and obese women.
Effective Dosage
Not specified.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Low carbohydrate diet (LCD) | decrease | inflammation | overweight and obese women | - | can improve | #1 |
Low carbohydrate diet (LCD) | decrease | obesity | overweight and obese women | - | can improve | #2 |
circadian rhythm disorders | increase | inflammation | obese individuals | - | can lead to increased | #3 |
adherence of LCD | decrease | circadian rhythm status | overweight and obese women | - | negative significant correlation | #4 |
LCD scores | decrease | odds of circadian rhythm disturbance | intermediate group and morning type persons compared to evening type | - | increased | #5 |
IL-1β and Galectin-3 | no change | relationship between LCD adherence and circadian rhythm | intermediate and morning type groups | - | destroyed the significance of this relationship | #6 |
IL-1β and Galectin-3 | neutral | relationship between LCD adherence and circadian rhythm | intermediate and morning type groups | - | may be considered as mediating markers | #7 |
Adherence of LCD | increase | circadian rhythm | overweight and obese women | - | can improve | #8 |
Adherence of LCD | decrease | inflammatory markers | overweight and obese women | - | reducing levels | #9 |
Adherence of LCD | decrease | obesity | overweight and obese women | - | may be considered as a treatment | #10 |
BACKGROUND: Low carbohydrate diet (LCD) can improve inflammation and obesity and also circadian rhythm disorders can lead to increased inflammation in obese individuals. The purpose of this study is to evaluate the association between adherence of LCD and circadian rhythm mediated by inflammatory markers including transforming growth factor-β (TGF-β), interleukin-1β (IL-1β) and Galectin-3 in overweight and obese women. METHODS: 304 women affected by overweight and obesity were enrolled. We evaluated LCD scores by Semi-quantitative food frequency questionnaire (FFQ) of 147 items. The morning-evening questionnaire (MEQ) was applied to evaluate the circadian rhythm. Biochemical parameters such as inflammatory markers and anthropometric components were assessed. RESULTS: There was a negative significant correlation between adherence of LCD and circadian rhythm status. In other words, as the LCD scores increased, the odds of circadian rhythm disturbance in intermediate group and morning type persons decreased compared to evening type. It was showed that, IL-1β and Galectin-3 in intermediate and morning type groups, destroyed the significance of this relationship and may be considered as mediating markers. CONCLUSION: Adherence of LCD can improve the circadian rhythm by reducing levels of inflammatory markers and may be considered as a treatment for obesity.