Walking Initiated 20 Minutes before the Time of Individual Postprandial Glucose Peak Reduces the Glucose Response in Young Men with Overweight or Obesity: A Randomized Crossover Study.
Study Goal
The researchers aimed to determine the optimal timing of postmeal walking to lower postprandial glucose (PPG) in overweight or obese young men.
Results Summary
Walking initiated 20 minutes before PPG peak (20iP) significantly reduced PPG, plasma insulin, and C-peptide concentrations compared to sitting or walking at PPG peak (iP). The effects were more pronounced in men with higher BMI or glucose iAUC values during sitting.
Population
Overweight or obese young men (age: 23.0 ± 4.3 y; BMI: 27.4 ± 2.8 kg/m²).
Effective Dosage
Walking at 50% maximal oxygen consumption for 30 minutes.
Duration
240-minute trials per session, with sessions separated by 6-14 days.
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
walking initiated 20 min before the PPGP (20iP) | decrease | 4-h incremental AUCs (iAUCs) for plasma PPG | overweight or obese young men | -0.6 mmol · L-1 · h | reduced | #1 |
walking initiated 20 min before the PPGP (20iP) | decrease | 4-h incremental AUCs (iAUCs) for plasma insulin | overweight or obese young men | -28.7% | reduced | #2 |
walking initiated at each participant's PPG-peak time (iP) | decrease | C-peptide concentrations | overweight or obese young men | -14.9% | lower | #3 |
walking initiated 20 min before the PPGP (20iP) | decrease | C-peptide concentrations | overweight or obese young men | -28.7% | lower | #4 |
walking initiated 20 min before the PPGP (20iP) | decrease | plasma insulin | overweight or obese young men | -11.1% | lower | #5 |
walking initiated 20 min before the PPGP (20iP) | decrease | C-peptide | overweight or obese young men | -8.3% | lower | #6 |
walking initiated at each participant's PPG-peak time (iP) | decrease | PPG | men with a BMI > 27.5 kg/m2 | -11.2% | reductions | #7 |
walking initiated 20 min before the PPGP (20iP) | decrease | PPG | men with a BMI > 27.5 kg/m2 | -14.7% | reductions | #8 |
walking initiated at each participant's PPG-peak time (iP) | decrease | glucose iAUC values | men with higher glucose iAUC values during SIT | -25.5% | reductions | #9 |
walking initiated 20 min before the PPGP (20iP) | decrease | glucose iAUC values | men with higher glucose iAUC values during SIT | -25.7% | reductions | #10 |
BACKGROUND: Although a single bout of postmeal exercise can lower postprandial glucose (PPG), its optimal timing remains unclear. OBJECTIVE: This study aimed to investigate the effect of exercise timing using an individualized approach on PPG in overweight or obese young men. METHODS: Twenty men [age: 23.0 ± 4.3 y; BMI (kg/m2): 27.4 ± 2.8] each completed three 240-min trials in a randomized order separated by 6-14 d: 1) sitting (SIT), 2) walking initiated at each participant's PPG-peak time (PPGP) (iP), and 3) walking initiated 20 min before the PPGP (20iP). For each participant, PPGP was predetermined using continuous glucose monitoring. Walking was performed at 50% maximal oxygen consumption for 30 min. Venous blood was collected at 15- and 30-min intervals for 0-120 min and 120-240 min, respectively. The primary outcome was plasma PPG. Generalized estimating equations were used for comparison between trials. RESULTS: Compared with SIT, the 4-h incremental AUCs (iAUCs) for plasma PPG (-0.6 mmol · L-1 · h; P = 0.047) and insulin (-28.7%, P < 0.001) were reduced in 20iP only, and C-peptide concentrations were lower after iP (-14.9%, P = 0.001) and 20iP (-28.7%, P < 0.001). Plasma insulin (-11.1%, P = 0.006) and C-peptide (-8.3%, P = 0.012) were lower due to the 20iP compared with iP treatment. Finally, PPG reductions due to iP and 20iP occurred only in men with a BMI > 27.5 kg/m2 (iP, -11.2%; 20iP, -14.7%; P = 0.047) and higher glucose iAUC values during SIT (iP, -25.5%; 20iP, -25.7%; P < 0.001). CONCLUSIONS: Walking initiated 20 min before PPGP lowered PPG and plasma insulin and C-peptide concentrations in young men with overweight or obesity, in particular in those with high BMI or glucose iAUC values during SIT; it also lowered plasma insulin and C-peptide concentrations more effectively than did exercise initiated at PPGP. This trial was registered at the Chinese Clinical Trial Registry (http://www.chictr.org.cn/index.aspx) as ChiCTR1900023175.