Daily vitamin D
Study Goal
The researchers aimed to assess the efficacy of different doses of vitamin D supplementation on 25(OH)D levels and related biochemical markers (including calcium) in children with excess weight.
Results Summary
The study found that higher doses of vitamin D (1000 and 2000 IU) increased 25(OH)D levels more effectively than 600 IU, but no significant changes were observed in serum calcium, phosphorus, or alkaline phosphatase levels across groups.
Population
Children and adolescents aged 6-13 years with a BMI Z-score ≥ 1 (excess weight).
Effective Dosage
600, 1000, and 2000 IU of vitamin D per day.
Duration
12 months.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
600 IU vitamin D | increase | 25(OH)D concentration | children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1 | from median 11.5 ng/mL to 23.1 ng/mL | increased | #1 |
1000 IU vitamin D | increase | 25(OH)D concentration | children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1 | from median 11.7 ng/mL to 25.6 ng/mL | increased | #2 |
2000 IU vitamin D | increase | 25(OH)D concentration | children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1 | from median 12.2 ng/mL to 28.6 ng/mL | increased | #3 |
600 IU vitamin D | decrease | prevalence of vitamin D deficiency (< 20 ng/mL) | children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1 | from 80.2% to 34% | decreased | #4 |
1000 IU vitamin D | decrease | prevalence of vitamin D deficiency (< 20 ng/mL) | children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1 | from 77.5% to 18.4% | decreased | #5 |
2000 IU vitamin D | decrease | prevalence of vitamin D deficiency (< 20 ng/mL) | children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1 | from 75.5% to 7.5% | decreased | #6 |
vitamin D supplementation | no change | iPTH response over time | children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1 | p value = 0.452 | did not differ significantly | #7 |
vitamin D supplementation | no change | calcium response over time | children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1 | p value = 0.670 | did not differ significantly | #8 |
vitamin D supplementation | no change | phosphorus response over time | children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1 | p value = 0.377 | did not differ significantly | #9 |
vitamin D supplementation | no change | alkaline phosphatase response over time | children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1 | p value = 0.895 | did not differ significantly | #10 |
1000 IU vitamin D | increase | 25(OH)D concentration | children with excess weight | compared with 600 IU/days | increased | #11 |
2000 IU vitamin D | increase | 25(OH)D concentration | children with excess weight | compared with 600 IU/days | increased | #12 |
vitamin D supplementation | no change | iPTH suppression | children with excess weight | - | no evidence of | #13 |
vitamin D supplementation | no change | serum calcium | children with excess weight | - | no change in | #14 |
vitamin D supplementation | no change | serum phosphorus | children with excess weight | - | no change in | #15 |
vitamin D supplementation | no change | serum alkaline phosphatase | children with excess weight | - | no change in | #16 |
PURPOSE: To assess the efficacy of different doses of vitamin D METHODS: A total of 378 children and adolescents, 6-13 years of age, with age- and sex-specific body mass index(BMI) Z-score ≥ 1(according to the World Health Organization criteria) were allocated to receive 600, 1000, and 2000 IU vitamin D RESULTS: Mean(SD) of age and BMI Z-score were 9.3 (1.7) years and 2.55 (0.73), respectively. The median (IQR) for 25(OH)D was 11.5 (8.9), 11.7 (10.5), 12.2 (10.2) ng/mL (28.75, 29.25, and 30.50 nmol/L) at baseline and 23.1 (8.0), 25.6 (8.3), 28.6 (10.4) ng/mL (57.75, 64.00, and 71.50 nmol/L) at the end of 12 months in 600, 1000, and 2000 IU, respectively (p values for dose, time, and the interaction being < 0.0001, < 0.0001,and 0.082, respectively). Prevalence of vitamin D deficiency (< 20 ng/mL) was 80.2, 77.5, and 75.5% in 600, 1000, and 2000 IU groups at baseline, respectively, which decreased to 34, 18.4, and 7.5%, respectively, at 12 months. Patterns of iPTH, calcium, phosphorus, and alkaline phosphatase response over time did not differ significantly among groups (p values = 0.452, 0.670, 0.377, 0.895, respectively). CONCLUSIONS: Increases in 25(OH)D concentration were found with supplementation of 1000 and 2000 IU, compared with 600 IU/days, whereas there was no evidence of iPTH suppression or change in serum calcium, phosphorus, and alkaline phosphatase among children with excess weight.