Melatonin ingestion before intradialytic exercise improves immune responses in hemodialysis patients.
Study Goal
The researchers aimed to investigate the effects of melatonin intake on systemic inflammation and immune responses during intradialytic exercise in hemodialysis patients.
Results Summary
The study found that melatonin intake alone or combined with intradialytic exercise showed potential immunoregulatory and anti-inflammatory effects, including significant changes in immune cell phenotypes. The combination of melatonin with exercise may be an appropriate anti-inflammatory therapy for hemodialysis patients.
Population
Thirteen hemodialysis (HD) patients.
Effective Dosage
3 mg, ingested 1 hour before exercise or equivalent time in control condition.
Duration
Not specified in the abstract.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin (MEL) intake | decrease | systemic inflammation and immune responses | hemodialysis (HD) patients | - | displays potential immunoregulatory and anti-inflammatory effects | #1 |
melatonin (MEL) intake associated with intradialytic exercise | decrease | systemic inflammation and immune responses | hemodialysis (HD) patients | - | displays potential immunoregulatory and anti-inflammatory effects | #2 |
HD therapy | decrease | natural killer (NK) cells | hemodialysis (HD) patients | - | induced a significant decrease | #3 |
HD therapy | decrease | CD8+ T cells | hemodialysis (HD) patients | - | induced a significant decrease | #4 |
the combination of MEL with intradialytic exercise | decrease | inflammation | HD patients | - | may be an appropriate anti-inflammatory therapy | #5 |
PURPOSE: The present study aimed to investigate the effects of melatonin (MEL) intake on systemic inflammation and immune responses during intradialytic exercise. METHODS: Thirteen hemodialysis (HD) patients volunteered to participate in the current randomized-crossover study. Immunological responses were monitored in four HD sessions at different conditions: [Exercise (EX) + MEL], [EX + Placebo (PLA)], [Control (CON) + MEL] and [CON + PLA]. MEL (3 mg) or PLA was ingested 1 h before starting exercise or the equivalent time in CON condition. During all sessions, peripheral blood samples were collected to assess c-reactive protein, complete blood count, and immune cells phenotypes before HD (T0), immediately after exercise (T1) and 1 h after exercise (T2) or at corresponding times in the CON condition. RESULTS: HD therapy induced a significant decrease in natural killer (NK) (p = 0.001, d = 0.85; p < 0.001, d = 1.19, respectively) and CD8 CONCLUSION: This pilot study provides the first evidence that MEL intake alone or associated with intradialytic exercise displays potential immunoregulatory and anti-inflammatory effects. The combination of MEL with intradialytic exercise may be an appropriate anti-inflammatory therapy for HD patients.