The effect of body acid-base state and manipulations on body glucose regulation in human.
Study Goal
The researchers aimed to test whether an alkalizing treatment (sodium bicarbonate) could improve postprandial glucose regulation in response to dietary acid load.
Results Summary
The study found that a 4-week high acid load diet increased plasma lactate and insulin resistance, with changes in lactate correlating with insulin resistance. Sodium bicarbonate was administered to directly assess its effect on glucose regulation, but specific results were not detailed in the abstract.
Population
Healthy participants (normal weight and overweight/obesity)
Effective Dosage
Not specified
Duration
4-week dietary intervention (sodium bicarbonate duration not specified)
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Long-term exposure to high dietary acid load | increase | insulin resistance and type 2 diabetes | - | - | has been associated with | #1 |
4-week high acid load diet | increase | plasma lactate | healthy participants | - | increased | #2 |
4-week high acid load diet | increase | insulin resistance | healthy participants | - | increased | #3 |
sodium bicarbonate (NaHCO₃) | neutral | postprandial glucose regulation | - | - | effect of an alkalizing treatment preload on | #4 |
Long-term exposure to high dietary acid load has been associated with insulin resistance and type 2 diabetes in epidemiological studies. However, it remains unclear whether the acid load of the diet translates to mild metabolic acidosis and whether it is responsible for the impairment in glucose regulation in humans. Previously, in a cross-sectional study we have reported that dietary acid load was not different between healthy individuals with normal weight and those with overweight/obesity, irrespective of insulin sensitivity. However, 4-week high acid load diet increased plasma lactate (a small component of the anion gap) and increased insulin resistance in healthy participants. The change in plasma lactate correlated significantly with the change in insulin resistance. Because cause-and-effect could not be evaluated in these settings, we sought to directly test the effect of an alkalizing treatment preload on postprandial glucose regulation. In a randomized placebo-controlled study with a crossover design, we administered sodium bicarbonate (NaHCO